Title:
TRANSDERMAL SYSTEM FOR SUSTAINED DELIVERY OF POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO2005056075
Kind Code:
A3
Abstract:
The present invention relates to a transdermal system for sustained delivery of high molecular weight hydrophilic drugs, especially peptide-, polypeptide- or protein-drugs and to methods of use thereof. The system comprises an apparatus that generates micro-channels in the skin of a subject in conjunction with a transdermal patch comprising at least one drug reservoir layer comprising a polymeric matrix and a therapeutic or immunogenic peptide, polypeptide or protein. The system provides sustained delivery of therapeutic or immunogenic agents, thereby achieving sustained therapeutic blood concentrations of these agents.
Inventors:
LEVIN GALIT (IL)
SACKS HAGIT (IL)
SACKS HAGIT (IL)
Application Number:
PCT/IL2004/001119
Publication Date:
February 02, 2006
Filing Date:
December 09, 2004
Export Citation:
Assignee:
TRANSPHARMA MEDICAL LTD (IL)
LEVIN GALIT (IL)
SACKS HAGIT (IL)
LEVIN GALIT (IL)
SACKS HAGIT (IL)
International Classes:
A61K9/70; A61N1/30; A61N1/32; A61B17/00; A61B18/14; A61K; A61M; (IPC1-7): A61K38/02; A61K38/28; A61K38/39; C07K2/00; C07K14/62; C07K14/78; A61N1/00; A61N1/30
Foreign References:
| US6490482B2 | 2002-12-03 | |||
| US5961482A | 1999-10-05 | |||
| US5418222A | 1995-05-23 | |||
| US20030143274A1 | 2003-07-31 | |||
| US5543098A | 1996-08-06 |
Other References:
1 November 2005 (2005-11-01), XP002987518, Retrieved from the Internet
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