Title:
TRANSFERRIN RECEPTOR BINDING PROTEINS AND CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2024/036096
Kind Code:
A3
Abstract:
Provided herein are proteins comprising one monovalent human TfR binding domain ("human TfR binding proteins"), proteins comprising one monovalent mouse TfR binding domain ("mouse TfR binding proteins"), conjugates comprising such human or mouse TfR binding proteins, e.g., human TfR binding proteins-dsRNA conjugates, pharmaceutical compositions comprising human TfR binding proteins or conjugates, and methods of treating CNS diseases (e.g., neurodegenerative disease such as neurodegenerative synucleinopathy or tauopathy) using human TfR binding proteins or conjugates.
Inventors:
ALAM RIAZUL (US)
ALVARADO ALBERTO (US)
ANDREWS FOREST (US)
BABB NICHOLAS (US)
BALASUBRAMANIAM DEEPA (US)
CHAUVIGNE-HINES LACIE (US)
CORTEZ GUILLERMO (US)
CROY JOHNNY (US)
DRIVER DAVID (US)
FELLOWS ROSS (US)
GIRARD DANIEL (US)
GONZALEZ VALCARCEL ISABEL (US)
KULKARNI NALINI (US)
LAWRENCE SCOTT (US)
LIU FENG (US)
TANI HIROAKI (US)
YORK JEREMY (US)
ALVARADO ALBERTO (US)
ANDREWS FOREST (US)
BABB NICHOLAS (US)
BALASUBRAMANIAM DEEPA (US)
CHAUVIGNE-HINES LACIE (US)
CORTEZ GUILLERMO (US)
CROY JOHNNY (US)
DRIVER DAVID (US)
FELLOWS ROSS (US)
GIRARD DANIEL (US)
GONZALEZ VALCARCEL ISABEL (US)
KULKARNI NALINI (US)
LAWRENCE SCOTT (US)
LIU FENG (US)
TANI HIROAKI (US)
YORK JEREMY (US)
Application Number:
PCT/US2023/071755
Publication Date:
April 25, 2024
Filing Date:
August 07, 2023
Export Citation:
Assignee:
ELI LILLY AND COMPANY (US)
International Classes:
A61K39/395
Attorney, Agent or Firm:
GAO, Xiaoguang et al. (US)
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