Title:
TRANSFORMING GROWTH FACTOR-β RECEPTOR INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/190425
Kind Code:
A1
Abstract:
A compound of formula (I) and a pharmaceutical composition comprising same. The compound of formula (I) can be used as a TGF-β receptor inhibitor, especially a TGFβRI inhibitor, and can be used for preventing or treating, for example, various related diseases mediated by TGFβRI(ALK5). ![]()
Inventors:
YU ZHIYONG (CN)
LI GANG (CN)
WANG KUNYAO (CN)
QIU QINGCHONG (CN)
JI BIN (CN)
SUN ZHAO (CN)
LI GANG (CN)
WANG KUNYAO (CN)
QIU QINGCHONG (CN)
JI BIN (CN)
SUN ZHAO (CN)
Application Number:
PCT/CN2021/081965
Publication Date:
September 30, 2021
Filing Date:
March 22, 2021
Export Citation:
Assignee:
ADLAI NORTYE BIOPHARMA CO LTD (CN)
International Classes:
C07D471/04; A61K31/4353; A61P25/28; A61P31/12; A61P35/00; A61P37/06
Domestic Patent References:
| WO2018017633A1 | 2018-01-25 | |||
| WO2017215506A1 | 2017-12-21 |
Foreign References:
| CN110066277A | 2019-07-30 | |||
| CN107663206A | 2018-02-06 |
Other References:
LI XINGZHOU, LIU FENG, LI SONG: "Research Progress on Transforming Growth Factor β Signal and its Signal Pathway Blockers", FOREIGN MEDICAL SCIENCES SECTION OF PHARMACY, MILITARY MEDICAL SCIENCES, INSTITUT FÜR PHARMAKOLOGIE UND TOXIKOLOGIE, CN, vol. 33, no. 5, 31 October 2006 (2006-10-31), CN, pages 331 - 335, XP055853037, ISSN: 1001-0971, DOI: 10.13220/j.cnki.jipr.2006.05.005
SUN LI-QIAN, MENG LI-QIANG, YAN CHAO-QUN, CUI DONG-XIAO, MIAO JUN-QIU, CHEN JING-RUN, LIANG TAI-GANG, LI QING-SHAN: "3D-QSAR Studies on 4-([1,2,4]Triazolo[1,5-α] pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole Analogues as Potent Inhibitors of Transforming Growth Factor-β Type Ⅰ Receptor Kinase", JIEGOU HUAXUE - CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, ZHONGGUO KEXUEYUAN FUJIAN WUZHI JIEGOU YANJIUSUO, CN, vol. 37, no. 4, 15 April 2018 (2018-04-15), CN, pages 517 - 530, XP055853038, ISSN: 0254-5861, DOI: 10.14102/j.cnki.0254-5861.2011-1766
SUN LI-QIAN, MENG LI-QIANG, YAN CHAO-QUN, CUI DONG-XIAO, MIAO JUN-QIU, CHEN JING-RUN, LIANG TAI-GANG, LI QING-SHAN: "3D-QSAR Studies on 4-([1,2,4]Triazolo[1,5-α] pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole Analogues as Potent Inhibitors of Transforming Growth Factor-β Type Ⅰ Receptor Kinase", JIEGOU HUAXUE - CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, ZHONGGUO KEXUEYUAN FUJIAN WUZHI JIEGOU YANJIUSUO, CN, vol. 37, no. 4, 15 April 2018 (2018-04-15), CN, pages 517 - 530, XP055853038, ISSN: 0254-5861, DOI: 10.14102/j.cnki.0254-5861.2011-1766
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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