Title:
TRANSGENIC ALGAE FOR DELIVERING ANTIGENS TO AN ANIMAL
Document Type and Number:
WIPO Patent Application WO2001098335
Kind Code:
A3
Abstract:
Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an expression vector, the expression vector comprising a nucleotide sequence coding for the biologically active protein, operably linked to a promoter. In one illustrated embodiment, the biologically active protein is an antigenic epitope and upon administration to the animal the algal cell induces an immune response in the host animal.
Inventors:
SAYRE RICHARD T (US)
WAGNER RICHARD E (US)
SIRIPORNADULSIL SURASAK (US)
FARIAS CARLOS (CL)
WAGNER RICHARD E (US)
SIRIPORNADULSIL SURASAK (US)
FARIAS CARLOS (CL)
Application Number:
PCT/US2001/019643
Publication Date:
May 16, 2002
Filing Date:
June 20, 2001
Export Citation:
Assignee:
PHYCOTRANSGENICS LLC (US)
UNIV OHIO STATE (US)
SAYRE RICHARD T (US)
WAGNER RICHARD E (US)
SIRIPORNADULSIL SURASAK (US)
FARIAS CARLOS (CL)
UNIV OHIO STATE (US)
SAYRE RICHARD T (US)
WAGNER RICHARD E (US)
SIRIPORNADULSIL SURASAK (US)
FARIAS CARLOS (CL)
International Classes:
A23K1/00; A23K1/16; A23K1/18; A61K39/05; A61K39/12; C07K14/195; C12N1/12; C12N15/82; A61K9/50; (IPC1-7): C12N15/82; C12N15/62; C12N15/10; C12N1/12; C07K14/195; A61K39/02
Domestic Patent References:
| WO1997039106A1 | 1997-10-23 | |||
| WO1999060838A1 | 1999-12-02 | |||
| WO1996011707A1 | 1996-04-25 |
Foreign References:
| EP0108580A1 | 1984-05-16 | |||
| EP0342824A1 | 1989-11-23 | |||
| EP0773295A2 | 1997-05-14 | |||
| EP0971034A1 | 2000-01-12 | |||
| EP1114867A1 | 2001-07-11 |
Other References:
BUROW MARK D ET AL: "Isolation of cDNA clones of genes induced upon transfer of Chlamydomonas reinhardtii cells to low CO-2.", PLANT MOLECULAR BIOLOGY, vol. 31, no. 2, 1996, pages 443 - 448, XP002192181, ISSN: 0167-4412
O'FARRELL CAROLINE L ET AL: "Differential expression of the virulence-associated protein p57 and characterization of its duplicated gene msa in virulent and attenuated strains of Renibacterium salmoninarum.", DISEASES OF AQUATIC ORGANISMS, vol. 38, no. 2, November 1999 (1999-11-01), pages 115 - 123, XP001064209, ISSN: 0177-5103
WIENS GREGORY D ET AL: "Antigenic and functional characterization of p57 produced by Renibacterium salmoninarum.", DISEASES OF AQUATIC ORGANISMS, vol. 37, no. 1, 23 June 1999 (1999-06-23), pages 43 - 52, XP001064210, ISSN: 0177-5103
PIGANELLI JON D ET AL: "Evaluation of a whole cell, p57- vaccine against Renibacterium salmoninarum.", DISEASES OF AQUATIC ORGANISMS, vol. 36, no. 1, 15 April 1999 (1999-04-15), pages 37 - 44, XP001064203, ISSN: 0177-5103
O'FARRELL CAROLINE L ET AL: "Differential expression of the virulence-associated protein p57 and characterization of its duplicated gene msa in virulent and attenuated strains of Renibacterium salmoninarum.", DISEASES OF AQUATIC ORGANISMS, vol. 38, no. 2, November 1999 (1999-11-01), pages 115 - 123, XP001064209, ISSN: 0177-5103
WIENS GREGORY D ET AL: "Antigenic and functional characterization of p57 produced by Renibacterium salmoninarum.", DISEASES OF AQUATIC ORGANISMS, vol. 37, no. 1, 23 June 1999 (1999-06-23), pages 43 - 52, XP001064210, ISSN: 0177-5103
PIGANELLI JON D ET AL: "Evaluation of a whole cell, p57- vaccine against Renibacterium salmoninarum.", DISEASES OF AQUATIC ORGANISMS, vol. 36, no. 1, 15 April 1999 (1999-04-15), pages 37 - 44, XP001064203, ISSN: 0177-5103
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