Title:
TRANSGENIC MICROORGANISM CAPABLE OF PRODUCING MUCONIC ACID, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/199111
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a microorganism which enables the production of muconic acid with good economic efficiency and high yield; and a method for producing muconic acid utilizing the microorganism. The purpose can be achieved by: a transgenic microorganism of which a host microorganism is a microorganism belonging to the genus Pseudomonas and has pcaH gene, pcaG gene, catA gene and catB gene on the chromosome thereof and in which the pcaH gene, the pcaG gene and the catB gene on the chromosome are deleted, and inserted pcaH gene and inserted pcaG gene can be expressed and inserted aroY gene is also expressed; a method for producing muconic acid using the transgenic microorganism; and others.
Inventors:
SONOKI TOMONORI (JP)
MASAI EIJI (JP)
KAMIMURA NAOFUMI (JP)
MASAI EIJI (JP)
KAMIMURA NAOFUMI (JP)
Application Number:
PCT/JP2018/016674
Publication Date:
November 01, 2018
Filing Date:
April 24, 2018
Export Citation:
Assignee:
UNIV HIROSAKI (JP)
International Classes:
C12N15/09; C12N1/21; C12P7/44
Domestic Patent References:
WO2012106257A1 | 2012-08-09 |
Other References:
JUNG, HM. ET AL.: "Metabolic engineering of Klebsiella pneumoniae for the production of cis, cis-muconic acid", APPL MICROBIOL BIOTECHNOL, vol. 99, 2015, pages 5217 - 5225, XP002780985
KIKUCHI, AKIHIRO ET AL.: "Production of muconic acid using lignin-derived phenols as raw materials", LECTURE ABSTRACTS OF THE CONFERENCE OF JAPAN SOCIETY OF BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2016
JOHNSON, C. W. ET AL.: "Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity", METABOLIC ENGINEERING COMMUNICATIONS, vol. 3, 2016, pages 111 - 119, XP055537227
JOHNSON, C. W. ET AL.: "Aromatic catabolic pathway selection for optimal production of pyruvate and lactate from lignin", METABOLIC ENGINEERING, vol. 28, pages 240 - 247, XP055537233
SONOKI, T. ET AL.: "Glucose-Free cis, cis-Muconic Acid Production via New Metabolic Design Corresponding to the Heterogeneity of lignin", ACS SUSTAINABLE CHEM. ENG., vol. 6, no. 1, 4 December 2017 (2017-12-04), pages 1256 - 1264, XP055537236
SONOKI, TOMONORI ET AL.: "Muconic acid production from lignin without glucose", BIOSCIENCE & INDUSTRY, vol. 76, 2018, pages 139 - 141
KIKUCHI, AKIHIRO ET AL.: "Production of muconic acid using lignin-derived phenols as raw materials", LECTURE ABSTRACTS OF THE CONFERENCE OF JAPAN SOCIETY OF BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, 2016
JOHNSON, C. W. ET AL.: "Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity", METABOLIC ENGINEERING COMMUNICATIONS, vol. 3, 2016, pages 111 - 119, XP055537227
JOHNSON, C. W. ET AL.: "Aromatic catabolic pathway selection for optimal production of pyruvate and lactate from lignin", METABOLIC ENGINEERING, vol. 28, pages 240 - 247, XP055537233
SONOKI, T. ET AL.: "Glucose-Free cis, cis-Muconic Acid Production via New Metabolic Design Corresponding to the Heterogeneity of lignin", ACS SUSTAINABLE CHEM. ENG., vol. 6, no. 1, 4 December 2017 (2017-12-04), pages 1256 - 1264, XP055537236
SONOKI, TOMONORI ET AL.: "Muconic acid production from lignin without glucose", BIOSCIENCE & INDUSTRY, vol. 76, 2018, pages 139 - 141
Attorney, Agent or Firm:
MORIMOTO, Toshiaki (JP)
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