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Title:
TRANSGENIC PRODUCTION OF HEPARIN
Document Type and Number:
WIPO Patent Application WO/2015/100160
Kind Code:
A3
Abstract:
The disclosure provides methods, cells and transgenic non human mammals for the production of heparin. Specifically, the method comprising providing a transgenic non human mammal or mammary epithelial cells modified to express one or more heparin biosynthesis enzymes, and harvesting heparin produced. Further provided are the cells and transgenic non human mammals thereof as well as the heparin obtained from these cells or transgenic non human mammals.

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Inventors:
MEADE HARRY M (US)
GAVIN WILLIAM G (US)
Application Number:
PCT/US2014/071471
Publication Date:
October 29, 2015
Filing Date:
December 19, 2014
Export Citation:
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Assignee:
LFB USA INC (US)
International Classes:
A01K67/027; C12N5/00; C12P19/26; C12P21/06
Foreign References:
US20050229261A12005-10-13
US20060253913A12006-11-09
US20050181482A12005-08-18
US20030140358A12003-07-24
US20120108802A12012-05-03
Other References:
BAIK ET AL.: "Toward a bioengineered heparin: challenges and strategies for metabolic engineering of mammalian cells.", BIOENGINEERED., vol. 3, no. 4, 2012, pages 227 - 31, XP055232942
JIA ET AL.: "Abundant human beta-defensin-1 expression in milk and mammary gland epithelium.", J PEDIATR., vol. 138, no. 1, 2001, pages 109 - 12, XP055232942
LORD ET AL.: "Bioengineered heparin - Is there a future for this form of the successful therapeutic?", BIOENGINEERED, vol. 5, no. 4, 2014, pages 222 - 226, XP055232943
Attorney, Agent or Firm:
JOHNSTONE, Oona M. (Greenfield & Sacks P.C.,600 Atlantic Avenu, Boston MA, US)
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