Title:
TRAP1 INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/265178
Kind Code:
A1
Abstract:
The present specification provides a compound that inhibits TRAP1 or a pharmaceutically acceptable salt thereof. In this case, the compound or the pharmaceutically acceptable salt thereof can inhibit the binding between TRAP1 and the client protein. In addition, the present specification provides: a pharmaceutical composition for the treatment of cancer or ophthalmic disease comprising a compound that inhibits TRAP1 or a pharmaceutically acceptable salt thereof; and use thereof.
Inventors:
KANG BYOUNG HEON (KR)
KIM SO-YEON (KR)
YOON NAM GU (KR)
KIM SO-YEON (KR)
YOON NAM GU (KR)
Application Number:
PCT/KR2022/001195
Publication Date:
December 22, 2022
Filing Date:
January 24, 2022
Export Citation:
Assignee:
SMARTIN BIO INC (KR)
ULSAN NAT INST SCIENCE & TECH UNIST (KR)
ULSAN NAT INST SCIENCE & TECH UNIST (KR)
International Classes:
C07F9/54; A61K31/662; A61K31/665; A61K31/675; A61P27/02; A61P35/00
Foreign References:
| KR20120008056A | 2012-01-25 | |||
| US20130072463A1 | 2013-03-21 | |||
| US20090214437A1 | 2009-08-27 | |||
| KR20210076875A | 2021-06-24 |
Other References:
ZHANG BO, WANG JING, HUANG ZHEN, WEI PENG, LIU YING, HAO JUNFENG, ZHAO LIJING, ZHANG FENGLIN, TU YAPING, WEI TAOTAO: "Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer", ONCOTARGET, vol. 6, no. 42, 29 December 2015 (2015-12-29), pages 44495 - 44508, XP093014563, DOI: 10.18632/oncotarget.6252
GOLEVA TATYANA N.; LYAMZAEV KONSTANTIN G.; ROGOV ANTON G.; KHAILOVA LJUDMILA S.; EPREMYAN KHOREN K.; SHUMAKOVICH GALINA P.; DOMNIN: "Mitochondria-targeted 1,4-naphthoquinone (SkQN) is a powerful prooxidant and cytotoxic agent", BIOCHIMICA ET BIOPHYSICA ACTA. BIOENERGETICS., AMSTERDAM, NL, vol. 1861, no. 8, 17 April 2020 (2020-04-17), NL , XP086184158, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2020.148210
LAN-FENG DONG, VICTORIA J. A. JAMESON, DAVID TILLY, JIRI CERNY, ELAHE MAHDAVIAN, ALVARO MARíN-HERNáNDEZ, LUZ HERNáN: "Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 286, no. 5, 4 February 2011 (2011-02-04), US , pages 3717 - 3728, XP055447239, ISSN: 0021-9258, DOI: 10.1074/jbc.M110.186643
DATABASE REGISTRY 16 November 1984 (1984-11-16), ANONYMOUS : "-Phosphonium, triphenyltetradecyl-, bromide (1:1) (CA INDEX NAME) ", XP093014567, retrieved from STN Database accession no. 25791-20-2
"Interplay between TRAP1 and Sirtuin-3 Modulates Mitochondrial Respiration and Oxidative Stress to Maintain Sternness of Glioma Stem Cells", CANCER RES, vol. 79, pages 1369 - 1382
"Control of tumor bioenergetics and survival stress signaling by mitochondrial Hsp90s", CANCER CELL, vol. 22, pages 331 - 344
"Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors", CLINICAL CANCER RESEARCH, vol. 18, pages 3562 - 3570
"Remington's Pharmaceutical Sciences", 1985, pages: 1418
"Handbook of Pharmaceutical Salts Properties, Selection, and Use", 2002
KANG ET AL., REGULATION OF TUMOR CELL MITOCHONDRIAL HOMEOSTASIS BY AN ORGANELLE-SPECIFIC HSP90 CHAPERONE NETWORK, 2007
CHAE ET AL., CONTROL OF TUMOR BIOENERGETICS AND SURVIVAL STRESS SIGNALING BY MITOCHONDRIAL HSP90S, 2012
XIE ET AL., THE MITOCHONDRIAL CHAPERONE TRAP1 AS A CANDIDATE TARGET OF ONCOTHERAPY, 2001
LETTINI ET AL., TRAP1:A VIABLE THERAPEUTIC TARGET FOR FUTURE CANCER TREATMENTS, 2017
ISSELBACHER ET AL.: "Harrison's Principles of Internal Medicine", 1996, pages: 1814 - 1882
GOLEVA TATYANA N.; LYAMZAEV KONSTANTIN G.; ROGOV ANTON G.; KHAILOVA LJUDMILA S.; EPREMYAN KHOREN K.; SHUMAKOVICH GALINA P.; DOMNIN: "Mitochondria-targeted 1,4-naphthoquinone (SkQN) is a powerful prooxidant and cytotoxic agent", BIOCHIMICA ET BIOPHYSICA ACTA. BIOENERGETICS., AMSTERDAM, NL, vol. 1861, no. 8, 17 April 2020 (2020-04-17), NL , XP086184158, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2020.148210
LAN-FENG DONG, VICTORIA J. A. JAMESON, DAVID TILLY, JIRI CERNY, ELAHE MAHDAVIAN, ALVARO MARíN-HERNáNDEZ, LUZ HERNáN: "Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 286, no. 5, 4 February 2011 (2011-02-04), US , pages 3717 - 3728, XP055447239, ISSN: 0021-9258, DOI: 10.1074/jbc.M110.186643
DATABASE REGISTRY 16 November 1984 (1984-11-16), ANONYMOUS : "-Phosphonium, triphenyltetradecyl-, bromide (1:1) (CA INDEX NAME) ", XP093014567, retrieved from STN Database accession no. 25791-20-2
"Interplay between TRAP1 and Sirtuin-3 Modulates Mitochondrial Respiration and Oxidative Stress to Maintain Sternness of Glioma Stem Cells", CANCER RES, vol. 79, pages 1369 - 1382
"Control of tumor bioenergetics and survival stress signaling by mitochondrial Hsp90s", CANCER CELL, vol. 22, pages 331 - 344
"Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors", CLINICAL CANCER RESEARCH, vol. 18, pages 3562 - 3570
"Remington's Pharmaceutical Sciences", 1985, pages: 1418
"Handbook of Pharmaceutical Salts Properties, Selection, and Use", 2002
KANG ET AL., REGULATION OF TUMOR CELL MITOCHONDRIAL HOMEOSTASIS BY AN ORGANELLE-SPECIFIC HSP90 CHAPERONE NETWORK, 2007
CHAE ET AL., CONTROL OF TUMOR BIOENERGETICS AND SURVIVAL STRESS SIGNALING BY MITOCHONDRIAL HSP90S, 2012
XIE ET AL., THE MITOCHONDRIAL CHAPERONE TRAP1 AS A CANDIDATE TARGET OF ONCOTHERAPY, 2001
LETTINI ET AL., TRAP1:A VIABLE THERAPEUTIC TARGET FOR FUTURE CANCER TREATMENTS, 2017
ISSELBACHER ET AL.: "Harrison's Principles of Internal Medicine", 1996, pages: 1814 - 1882
Attorney, Agent or Firm:
IPS PATENT FIRM (KR)
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