Title:
TREATMENT AGENT FOR COGNITIVE DISORDERS, INDUCED BY AMYLOID β-PROTEIN, THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE, AND TREATMENT METHOD AND PATHOLOGICAL ANALYSIS METHOD RELATED TO THESE
Document Type and Number:
WIPO Patent Application WO/2014/171434
Kind Code:
A1
Abstract:
The present invention addresses the issue of providing an anti-Alzheimer's agent that uses an amyloid β-protein as the mechanism of action therefor but that is different from conventional mechanisms of action. This therapeutic agent for Alzheimer's disease contains a cognitive disorder treatment agent induced by an amyloid β-protein containing a peptide comprising an amino acid sequence indicated by SEQ ID NO. 1, or a peptide similar to same, in particular a peptide including an amino acid sequence indicated by SEQ ID NO. 2 being a partial sequence of SEQ ID NO. 1; and is characterized by containing said treatment agent. SEQ ID NO. 1: VLSSQQFLHRGHQPPPEMAGHSLASSHRNSMIPSAAT; SEQ ID NO. 2: HRGHQPPPEMA
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Inventors:
INOUE TSUYOSHI (JP)
SUZUKI TOSHIHARU (JP)
BAN SAORI (JP)
SUZUKI TOSHIHARU (JP)
BAN SAORI (JP)
Application Number:
PCT/JP2014/060665
Publication Date:
October 23, 2014
Filing Date:
April 15, 2014
Export Citation:
Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61P25/00; A61K38/00; A61P25/28; C07K7/06; C07K7/08; C07K14/47
Domestic Patent References:
| WO2012137502A1 | 2012-10-11 | |||
| WO2009075084A1 | 2009-06-18 | |||
| WO2002040451A2 | 2002-05-23 | |||
| WO2009017467A1 | 2009-02-05 |
Foreign References:
| EP0296560A2 | 1988-12-28 | |||
| US3391142A | 1968-07-02 | |||
| US20040198778A1 | 2004-10-07 | |||
| US7666982B2 | 2010-02-23 | |||
| US7807777B2 | 2010-10-05 |
Other References:
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OKOCHI ET AL., EMBO J, vol. 21, 2002, pages 5408 - 5416
ARAKI ET AL., J BIOL CHEM, vol. 279, 2004, pages 24343 - 24354
HATA ET AL., J BIOL CHEM, vol. 284, 2009, pages 36024 - 36033
PIAO ET AL., PLOS ONE, vol. 8, 2013, pages E62431
RAMPON ET AL., NAT NEUROSCI, vol. 3, 2000, pages 238 - 244
DE LIMA ET AL., BEHAV BRAIN RES, vol. 156, 2005, pages 139 - 143
MIZUMARU C. ET AL.: "Suppression of APP- containing vesicle trafficking and production of beta-amyloid by AID/DHHC-12 protein.", JOURNAL OF NEUROCHEMISTRY, vol. 111, no. 5, 2009, pages 1213 - 1224, XP055286784
HATA S. ET AL.: "Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma- secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma- secretase dysfunction.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 52, 2009, pages 36024 - 36033, XP007916031
SAORI HANEDA ET AL.: "Makunai Tanpaku Bunkai Koso Presenilin no Seibutsugaku Alcadein to y Secretase", BRAIN 21, vol. 15, no. 4, 2012, pages 449 - 453, XP008181472
DE STROOPER ET AL., NAT REV NEUROL, vol. 6, 2010, pages 99 - 107
LAMBERT ET AL., PROC NATL ACAD SCI USA, vol. 95, 1998, pages 6448 - 6453
WALSH ET AL., NATURE, vol. 416, 2002, pages 535 - 539
CLEARY ET AL., NAT NEUROSCI, vol. 8, 2005, pages 79 - 84
BALDUCCI ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 2295 - 2300
BROUILLETTE ET AL., J NEUROSCI, vol. 32, 2012, pages 7852 - 7861
HAAPASALO; KOVACS, J ALZHEIMERS DIS, vol. 25, 2011, pages 3 - 28
DE STROOPER ET AL., NATURE, vol. 398, 1999, pages 518 - 522
OKOCHI ET AL., EMBO J, vol. 21, 2002, pages 5408 - 5416
ARAKI ET AL., J BIOL CHEM, vol. 279, 2004, pages 24343 - 24354
HATA ET AL., J BIOL CHEM, vol. 284, 2009, pages 36024 - 36033
PIAO ET AL., PLOS ONE, vol. 8, 2013, pages E62431
RAMPON ET AL., NAT NEUROSCI, vol. 3, 2000, pages 238 - 244
DE LIMA ET AL., BEHAV BRAIN RES, vol. 156, 2005, pages 139 - 143
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
Patent business corporation SSINPAT (JP)
Patent business corporation SSINPAT (JP)
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