Title:
TREATMENT FOR CENTRAL NERVOUS SYSTEM DISORDERS
Document Type and Number:
WIPO Patent Application WO2003020212
Kind Code:
A3
Abstract:
Compositions that include an Abeta polypeptide linked to a non-Abeta polypeptide are described, as well as methods of using such compositions.
Inventors:
PODUSLO JOSEPH F (US)
CURRAN GEOFFRY L (US)
CURRAN GEOFFRY L (US)
Application Number:
PCT/US2002/027291
Publication Date:
February 19, 2004
Filing Date:
August 27, 2002
Export Citation:
Assignee:
MAYO FOUNDATION (US)
PODUSLO JOSEPH F (US)
CURRAN GEOFFRY L (US)
PODUSLO JOSEPH F (US)
CURRAN GEOFFRY L (US)
International Classes:
A61B5/05; A61B5/055; A61K38/00; A61K38/22; A61K38/44; A61K39/395; A61K47/48; A61K51/00; A61P25/28; C07K14/47; C07K16/18; (IPC1-7): C07K16/00; A01N37/18; A61K38/00; C07K17/00; C07K17/14; C12N9/00; G01N33/53; G01N33/542
Foreign References:
| US5231000A | 1993-07-27 |
Other References:
SAITO ET AL.: "Vector-mediated delivery of 125I-labeled beta-amyloid peptide Abeta1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the Abeta 1-40/vector complex", PROC. NATL. ACAD. SCI. USA, vol. 92, October 1995 (1995-10-01), pages 10227 - 10231, XP002090767
DEMATTOS ET AL.: "Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease", PROC. NATL. ACAD. SCI. USA, vol. 98, 17 July 2001 (2001-07-17), pages 8850 - 8855, XP001156930
JANUS ET AL.: "Abeta peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease", NATURE, vol. 408, 28 December 2000 (2000-12-28), pages 979 - 982, XP002969677
See also references of EP 1434801A4
DEMATTOS ET AL.: "Peripheral anti-Abeta antibody alters CNS and plasma Abeta clearance and decreases brain Abeta burden in a mouse model of Alzheimer's disease", PROC. NATL. ACAD. SCI. USA, vol. 98, 17 July 2001 (2001-07-17), pages 8850 - 8855, XP001156930
JANUS ET AL.: "Abeta peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease", NATURE, vol. 408, 28 December 2000 (2000-12-28), pages 979 - 982, XP002969677
See also references of EP 1434801A4
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