Title:
TREATMENT OF CONDITIONS ASSOCIATED WITH STRESS GRANULE FORMATION
Document Type and Number:
WIPO Patent Application WO/2023/147340
Kind Code:
A3
Abstract:
Disclosed herein are methods of treating and/or prophylaxis of a disease or condition associated with cellular stress granule formation in a mammal via administration of small molecule compounds. Also disclosed herein are chemical compounds effective in treating diseases or conditions associated with aberrant cellular stress responses and/or stress granule formation.
More Like This:
Inventors:
RAYMAN JOSEPH B (US)
LANDRY DONALD W (US)
DENG SHI-XIAN (US)
LANDRY DONALD W (US)
DENG SHI-XIAN (US)
Application Number:
PCT/US2023/061236
Publication Date:
September 14, 2023
Filing Date:
January 25, 2023
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
A61K31/095; A61K31/33; A61K31/505; A61K31/395
Foreign References:
| US4711961A | 1987-12-08 |
Other References:
WANG YUREN, WALLACH JASON, DUANE STEPHANIE, WANG YUAN, WU JIANGHONG, WANG JEFFREY, ADEJARE ADEBOYE, MA HAICHING: "Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. Volume 11, pages 1369 - 1382, XP093092007, DOI: 10.2147/DDDT.S124977
PARK ET AL.: "METABOLISM OF FLUORINE-CONTAINING DRUGS", ANNU. REV. PHARMACOL. TOXICOL., vol. 41, 2001, pages 443 - 70, XP009114978, DOI: 10.1146/annurev.pharmtox.41.1.443
MARCELO ADRIANA, KOPPENOL REBEKAH, DE ALMEIDA LUÍS PEREIRA, MATOS CARLOS A., NÓBREGA CLÉVIO: "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?", CELL DEATH & DISEASE, vol. 12, no. 6, XP093092005, DOI: 10.1038/s41419-021-03873-8
PARK ET AL.: "METABOLISM OF FLUORINE-CONTAINING DRUGS", ANNU. REV. PHARMACOL. TOXICOL., vol. 41, 2001, pages 443 - 70, XP009114978, DOI: 10.1146/annurev.pharmtox.41.1.443
MARCELO ADRIANA, KOPPENOL REBEKAH, DE ALMEIDA LUÍS PEREIRA, MATOS CARLOS A., NÓBREGA CLÉVIO: "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?", CELL DEATH & DISEASE, vol. 12, no. 6, XP093092005, DOI: 10.1038/s41419-021-03873-8
Attorney, Agent or Firm:
RABINOWITZ, Aaron B. et al. (US)
Download PDF:
Previous Patent: APPARATUS FOR A QUICK RELEASE CUTTING DEVICE BLADE ASSEMBLY
Next Patent: OROFACIAL MYOFUNCTIONAL THERAPY METHODS AND SYSTEMS
Next Patent: OROFACIAL MYOFUNCTIONAL THERAPY METHODS AND SYSTEMS