Title:
TREATMENT OF A DEMYELINATING DISEASE OF THE CENTRAL NERVOUS SYSTEM (CNS) WITH SATRALIZUMAB
Document Type and Number:
WIPO Patent Application WO/2023/095852
Kind Code:
A1
Abstract:
The invention provides a means for a treatment for a demyelinating disease of the central nervous system (CNS) characterized by the presence of an anti-myelin oligodendrocyte glycoprotein (MOG) antibody, and also for reducing the risk of relapse in the demyelinating disease, comprising an anti-IL-6 receptor antibody or antigen binding fragment thereof.
Inventors:
OZAWA TAKATOSHI (JP)
YAMASHIRO MAI (JP)
ITO HAJIME (JP)
YOSHIDA SHUNSUKE (JP)
SMITH JILLIAN (GB)
VODOPIVEC IVANA (CH)
LENNON-CHRIMES SIAN (GB)
KLINGELSCHMITT GAELLE (CH)
VON BUEDINGEN HANS-CHRISTIAN (CH)
SILBER BAUMANN HANNA (CH)
YAMASHIRO MAI (JP)
ITO HAJIME (JP)
YOSHIDA SHUNSUKE (JP)
SMITH JILLIAN (GB)
VODOPIVEC IVANA (CH)
LENNON-CHRIMES SIAN (GB)
KLINGELSCHMITT GAELLE (CH)
VON BUEDINGEN HANS-CHRISTIAN (CH)
SILBER BAUMANN HANNA (CH)
Application Number:
PCT/JP2022/043437
Publication Date:
June 01, 2023
Filing Date:
November 25, 2022
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
HOFFMANN LA ROCHE (CH)
HOFFMANN LA ROCHE (CH)
International Classes:
A61K39/395; A61K31/52; A61K31/5377; A61K31/573; A61P25/00; A61P37/06
Foreign References:
| US20180148509A1 | 2018-05-31 | |||
| US20110098450A1 | 2011-04-28 |
Other References:
RINGELSTEIN MARIUS, AYZENBERG ILYA, LINDENBLATT GERO, FISCHER KATINKA, GAHLEN ANNA, NOVI GIOVANNI, HAYWARD-KÖNNECKE HELEN, SCHIPPL: "Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG–Associated Disease and Neuromyelitis Optica Spectrum Disorders", NEUROLOGY - NEUROIMMUNOLOGY NEUROINFLAMMATION, vol. 9, no. 1, 1 January 2022 (2022-01-01), pages e1100, XP093068098, DOI: 10.1212/NXI.0000000000001100
RIGAL J., PUGNET G., CIRON J., LÉPINE Z., BIOTTI D.: "Off-label use of tocilizumab in neuromyelitis optica spectrum disorders and MOG-antibody-associated diseases: A case-series", MULTIPLE SCLEROSIS AND RELATED DISORDERS, ELSEVIER, NL, vol. 46, 1 November 2020 (2020-11-01), NL , pages 102483, XP093068101, ISSN: 2211-0348, DOI: 10.1016/j.msard.2020.102483
ELSBERND PAUL M., HOFFMAN WILLIAM R., CARTER JONATHAN L., WINGERCHUK DEAN M.: "Interleukin-6 inhibition with tocilizumab for relapsing MOG-IgG associated disorder (MOGAD): A case-series and review", MULTIPLE SCLEROSIS AND RELATED DISORDERS, ELSEVIER, NL, vol. 48, 1 February 2021 (2021-02-01), NL , pages 102696, XP093068102, ISSN: 2211-0348, DOI: 10.1016/j.msard.2020.102696
RIGAL J., PUGNET G., CIRON J., LÉPINE Z., BIOTTI D.: "Off-label use of tocilizumab in neuromyelitis optica spectrum disorders and MOG-antibody-associated diseases: A case-series", MULTIPLE SCLEROSIS AND RELATED DISORDERS, ELSEVIER, NL, vol. 46, 1 November 2020 (2020-11-01), NL , pages 102483, XP093068101, ISSN: 2211-0348, DOI: 10.1016/j.msard.2020.102483
ELSBERND PAUL M., HOFFMAN WILLIAM R., CARTER JONATHAN L., WINGERCHUK DEAN M.: "Interleukin-6 inhibition with tocilizumab for relapsing MOG-IgG associated disorder (MOGAD): A case-series and review", MULTIPLE SCLEROSIS AND RELATED DISORDERS, ELSEVIER, NL, vol. 48, 1 February 2021 (2021-02-01), NL , pages 102696, XP093068102, ISSN: 2211-0348, DOI: 10.1016/j.msard.2020.102696
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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