Title:
TREATMENT OF DISEASE WITH EPOR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2022/025204
Kind Code:
A1
Abstract:
The present disclosure provides an anti-EpoR peptide for use in the treatment of a disease such as cancer. In the description, a peptide which has the structure: -[SCHFGPLTWVCK]- and which is intended to be used for antagonizing an Epo hetero receptor selectively in the presence of erythropoietin (Epo) or an equivalent thereof, a modified peptide of the peptide, a prodrug of the modified peptide, or a salt of the peptide, the modified peptide or the prodrug (wherein, in the formula, an alphabetical letter represents a one-letter code for an amino acid residue) is provided. In one embodiment, a disease, a disorder or a symptom each characterized by the occurrence of a cell expressing an Epo hetero receptor is treated or prevented.
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Inventors:
KOUJI HIROYUKI (JP)
OCHI HIROSHI (JP)
SAKAGUCHI TAKEHISA (JP)
YASUDA YOSHIKO (JP)
OCHI HIROSHI (JP)
SAKAGUCHI TAKEHISA (JP)
YASUDA YOSHIKO (JP)
Application Number:
PCT/JP2021/028154
Publication Date:
February 03, 2022
Filing Date:
July 29, 2021
Export Citation:
Assignee:
EPO MED INC (JP)
International Classes:
A61K38/10; A61K31/138; A61K31/704; A61K39/395; A61P15/00; A61P17/02; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07K7/08; C07K14/505
Domestic Patent References:
| WO2020054813A1 | 2020-03-19 | |||
| WO2020054813A1 | 2020-03-19 |
Foreign References:
| JP2003201252A | 2003-07-18 | |||
| JP2020129269A | 2020-08-27 |
Other References:
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BRINES, M. ET AL.: "The Receptor That Tames the Innate Immune Response", MOLECULAR MEDICINE, vol. 18, 2012, pages 486 - 496, XP055903449
KRANTZ S.B., BLOOD, vol. 77, 1991, pages 419 - 434
D'ANDREA A. D. ET AL., CELL, vol. 57, 1989, pages 277 - 285
YASUDA Y. ET AL., DEVELOP. GROWTH DIFFER., vol. 35, 1993, pages 711 - 722
MARTI H. H. ET AL., EUR. J. NEUROSCI., vol. 8, 1996, pages 666 - 676
YASUDA Y. ET AL., J. BIOL. CHEM., vol. 273, 1998, pages 25381 - 25387
MOL CELL, vol. 33, no. 2, 30 January 2009 (2009-01-30), pages 266 - 74
R S SYED ET AL., NATURE, vol. 395, no. 6701, 1 October 1998 (1998-10-01), pages 511 - 6
ZHANG B. K. ET AL., MOL CELL, vol. 33, 2009, pages 266
MOL MED, vol. 18, no. 1, 9 May 2012 (2012-05-09), pages 486 - 96
NOBUO IZUMIYAMARUZEN ET AL., FUNDAMENTALS AND EXPERIMENTS OF PEPTIDE SYNTHESIS, 1985
MARUZEN: "The Fifth Series of Experimental Chemistry", POLYMER CHEMISTRY, vol. 26, 2007
STRECKER, A.: "Ueber die kunstliche Bildung der Milchsaure und einen neuen, dem Glycocoll homologen Korper", ANN, vol. 75, 8 January 1950 (1950-01-08), pages 27 - 45
STRECKER, A.: "Ueber einen neuen aus Aldehyd-Ammoniak und Blausaure entstehenden Korper", ANN, vol. 91, 8 January 1954 (1954-01-08), pages 349 - 351
BRINES, M. ET AL.: "The Receptor That Tames the Innate Immune Response", MOLECULAR MEDICINE, vol. 18, 2012, pages 486 - 496, XP055903449
KRANTZ S.B., BLOOD, vol. 77, 1991, pages 419 - 434
D'ANDREA A. D. ET AL., CELL, vol. 57, 1989, pages 277 - 285
YASUDA Y. ET AL., DEVELOP. GROWTH DIFFER., vol. 35, 1993, pages 711 - 722
MARTI H. H. ET AL., EUR. J. NEUROSCI., vol. 8, 1996, pages 666 - 676
YASUDA Y. ET AL., J. BIOL. CHEM., vol. 273, 1998, pages 25381 - 25387
MOL CELL, vol. 33, no. 2, 30 January 2009 (2009-01-30), pages 266 - 74
R S SYED ET AL., NATURE, vol. 395, no. 6701, 1 October 1998 (1998-10-01), pages 511 - 6
ZHANG B. K. ET AL., MOL CELL, vol. 33, 2009, pages 266
MOL MED, vol. 18, no. 1, 9 May 2012 (2012-05-09), pages 486 - 96
NOBUO IZUMIYAMARUZEN ET AL., FUNDAMENTALS AND EXPERIMENTS OF PEPTIDE SYNTHESIS, 1985
MARUZEN: "The Fifth Series of Experimental Chemistry", POLYMER CHEMISTRY, vol. 26, 2007
STRECKER, A.: "Ueber die kunstliche Bildung der Milchsaure und einen neuen, dem Glycocoll homologen Korper", ANN, vol. 75, 8 January 1950 (1950-01-08), pages 27 - 45
STRECKER, A.: "Ueber einen neuen aus Aldehyd-Ammoniak und Blausaure entstehenden Korper", ANN, vol. 91, 8 January 1954 (1954-01-08), pages 349 - 351
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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