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Patent Searching and Data


Title:
TREATMENT OF DISEASES INVOLVING THE HIPPO PATHWAY
Document Type and Number:
WIPO Patent Application WO/2015/073813
Kind Code:
A3
Abstract:
Provided herein are interfering molecules and pharmaceutical combinations comprising such interfering molecules that modulate the Hippo signaling pathway. Also provided are methods of treating and preventing a disease or condition associated disruption of a Hippo signaling pathway component, such as skeletal muscle disorders and cancers, where the method comprises administering to a subject in need thereof an interfering molecule or pharmaceutical composition described herein.

Inventors:
LINARDIC, Corinne, M. (Division Of Pediatric Hematology-oncology, Box 102382 DumcDurham, NC, 27710, US)
CROSE, Lisa, E., S. (2918 Sparger Road, Durham, NC, 27705, US)
CHI, Jen-tsan (119 Basswood Court, Chapel Hill, NC, 27514, US)
Application Number:
US2014/065689
Publication Date:
October 15, 2015
Filing Date:
November 14, 2014
Export Citation:
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Assignee:
DUKE UNIVERSITY (2812 Erwin Rd, Durham, NC, 27705, US)
LINARDIC, Corinne, M. (Division Of Pediatric Hematology-oncology, Box 102382 DumcDurham, NC, 27710, US)
CROSE, Lisa, E., S. (2918 Sparger Road, Durham, NC, 27705, US)
CHI, Jen-tsan (119 Basswood Court, Chapel Hill, NC, 27514, US)
International Classes:
A61K38/00; A61P21/00; A61P35/00; C07D403/14
Foreign References:
US20130143948A12013-06-06
US7556942B22009-07-07
US8486903B22013-07-16
US20050112552A12005-05-26
Other References:
JUDSON, RN ET AL.: "Constitutive Expression of YES-Associated Protein (YAP) in Augult Skeletal Muscle Fibres Induces Muscle Atrophy and Myopathy.", PLOSONE., 27 March 2013 (2013-03-27), pages 1 - 12 ; pages 1, 5, XP002701148
PARK, HW ET AL.: "The Regulation of Hippo Pathway and Implications For Anticancer Drug Development.", TRENDS IN PHARMACOLOGICAL SCIENCES., vol. 34, no. 10, October 2013 (2013-10-01), pages 581 - 589, XP055230836
HULMI, JJ ET AL.: "Muscle Protein Synthesis, mTORC1/MAPK/Hippo Signaling, and Capillary Density are Altered by Blocking of Myostatin and Activins.", AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM, vol. 304, 31 October 2012 (2012-10-31), pages E46, XP055230840
HARVEY, KF ET AL.: "The Hippo Pathway and Human Cancer.", NATURES REVIEW CANCER., vol. 13, April 2013 (2013-04-01), pages 246 - 257, XP055172680
RICHTER, AM ET AL.: "The RASSF Proteins in Cancer: From Epigenetic Silencing to Functional Characterization.", BIOCHIMCA ET BIOPHYSICA ACTA., 2009, pages 1 - 15, XP026639948
Attorney, Agent or Firm:
LEWIS, Jessica (Quarles & Brady Llp, 33 East Main St. Suite 90, Madison WI, 53703-3095, US)
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