Title:
TREATMENT OF DISORDERS BY IMPLANTING STEM CELLS AND/OR PROGENY THEREOF INTO GASTROINTESTINAL ORGANS
Document Type and Number:
WIPO Patent Application WO2001078752
Kind Code:
A3
Abstract:
A method of treating a disorder, typically a gastrointestinal disorder, that includes implanting stem cells and/or progeny thereof into a gastrointestinal organ of a subject. Also, a method of producing enhanced levels of insulin that includes implanting stem cells and/or progeny thereof into the pancreas of a subject.
Inventors:
PASRICHA PANKAJ JAY (US)
MICCI MARIA A (US)
MICCI MARIA A (US)
Application Number:
PCT/US2001/011999
Publication Date:
May 23, 2002
Filing Date:
April 12, 2001
Export Citation:
Assignee:
UNIV TEXAS (US)
PASRICHA PANKAJ JAY (US)
MICCI MARIA A (US)
PASRICHA PANKAJ JAY (US)
MICCI MARIA A (US)
International Classes:
A61K35/34; A61P1/00; A61K35/30; A61P1/16; A61P1/18; C12N5/0797; A61K35/12; (IPC1-7): A61K35/12; A61K35/34; A61P1/00
Domestic Patent References:
| WO1999067363A1 | 1999-12-29 | |||
| WO1998007841A1 | 1998-02-26 | |||
| WO2000003001A1 | 2000-01-20 |
Other References:
CORNELIUS J G ET AL: "In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas.", HORMONE AND METABOLIC RESEARCH, vol. 29, no. 6, 1997, pages 271 - 277, XP000864742
SCHEFFOLD Y C ET AL: "Purified allogeneic hematopoietic stem cell transplantation prevents autoimmune diabetes and induces tolerance to donor matched islets.", BLOOD, vol. 94, no. 10 Suppl. 1 Part 1, 15 November 1999 (1999-11-15), 41st Annual Meeting of the American Society of Hematology; New Orleans, USA; 3-7 December 1999, pages 664a, XP002186702
MICCI M-A ET AL: "Successful transplantation of neuronal stem cells in the gastrointestinal tract with evidence of morphological and functional differentiation.", GASTROENTEROLOGY, vol. 118, no. 4 Suppl. 2 Part 1, April 2000 (2000-04-01), 101st Annual Meeting of the American Gastroenterological Association and the Digestive Disease Week; San Diego, USA; 21-24 May 2000, pages A185, XP001042286
MICCI M-A ET AL: "Successful transplantation of neuronal stem cells in the gastrointestinal tract with evidence of morphological and functional differentiation.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 26, no. 1-2, 2000, 30th Annual Meeting of the Society of Neuroscience; New Orleans, USA; 4-9 November 2000, XP001042287
MICCI M-A ET AL: "Neural stem cells express RET, produce nitric oxide, and survive transplantation in the gastrointestinal tract.", GASTROENTEROLOGY, vol. 121, no. 4, October 2001 (2001-10-01), pages 757 - 766, XP002186703
SCHEFFOLD Y C ET AL: "Purified allogeneic hematopoietic stem cell transplantation prevents autoimmune diabetes and induces tolerance to donor matched islets.", BLOOD, vol. 94, no. 10 Suppl. 1 Part 1, 15 November 1999 (1999-11-15), 41st Annual Meeting of the American Society of Hematology; New Orleans, USA; 3-7 December 1999, pages 664a, XP002186702
MICCI M-A ET AL: "Successful transplantation of neuronal stem cells in the gastrointestinal tract with evidence of morphological and functional differentiation.", GASTROENTEROLOGY, vol. 118, no. 4 Suppl. 2 Part 1, April 2000 (2000-04-01), 101st Annual Meeting of the American Gastroenterological Association and the Digestive Disease Week; San Diego, USA; 21-24 May 2000, pages A185, XP001042286
MICCI M-A ET AL: "Successful transplantation of neuronal stem cells in the gastrointestinal tract with evidence of morphological and functional differentiation.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 26, no. 1-2, 2000, 30th Annual Meeting of the Society of Neuroscience; New Orleans, USA; 4-9 November 2000, XP001042287
MICCI M-A ET AL: "Neural stem cells express RET, produce nitric oxide, and survive transplantation in the gastrointestinal tract.", GASTROENTEROLOGY, vol. 121, no. 4, October 2001 (2001-10-01), pages 757 - 766, XP002186703
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