Title:
TREATMENT METHOD WITH IAP INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/098771
Kind Code:
A1
Abstract:
Improved methods for treating hepatitis B (HB) in patients with (5S, 5'S, 8S, 8'S, 10aR, 10a'R) -3, 3'- (1, 3-phenylenedisulfonyl) bis (N-benzhydryl-5- ( (S) -2- (methylamino) propanamido) -6-oxodecahydropyrrolo [1, 2-a] [1, 5] diazocine-8-carboxamide) (Compound (I) ) are disclosed herein. Dosing regimens of Compound (I) for the treatment of HBV infection are provided.
Inventors:
ZHAI YIFAN (CN)
ZHANG XIAOYONG (CN)
HOU JINLIN (CN)
YANG DAJUN (CN)
ZHANG XIAOYONG (CN)
HOU JINLIN (CN)
YANG DAJUN (CN)
Application Number:
PCT/CN2020/130068
Publication Date:
May 27, 2021
Filing Date:
November 19, 2020
Export Citation:
Assignee:
ASCENTAGE PHARMA SUZHOU CO LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
International Classes:
A61K31/407; A61P1/16; A61P31/20; C07D487/04; C07D519/00
Domestic Patent References:
| WO2019101047A1 | 2019-05-31 | |||
| WO2014031487A1 | 2014-02-27 |
Other References:
ASCENTAGE PHARMA. GROUP INC.: "A Clinical Study of APG-1387 in Combination With Entecavir in Patients With Chronic Hepatitis B.", CLINICALTRIALS.GOV IDENTIFIER: NCT04568265, 12 October 2020 (2020-10-12), pages 1 - 5, XP009528089
LIU HONGYAN; HOU JINLIN; ZHANG XIAOYONG: "Targeting cIAPs, a New Option for Functional Cure of Chronic Hepatitis B Infection?", VIROLOGICA SINICA., vol. 33, no. 5, 29 October 2018 (2018-10-29), pages 459 - 461, XP036635966, ISSN: 1674-0769, DOI: 10.1007/s12250-018-0062-x
WENTAO PAN, QIUYUN LUO, XIANGLEI YAN, LUPING YUAN, HANJIE YI, LIN ZHANG, BAOXIA LI, YUXIN ZHANG, JIAN SUN, MIAO-ZHEN QIU, DA-JUN Y: "A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity.", BIOCHEMICAL PHARMACOLOGY., vol. 154, 18 April 2018 (2018-04-18), pages 127 - 135, XP055502790, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.04.020
MAK LUNG-YI; SETO WAI-KAY; YUEN MAN-FUNG: "Future Therapies for Functional Cure of Chronic HBV: Review of Investigational Drugs in Phase 1 and 2 Development.", CURRENT HEPATOLOGY REPORTS., vol. 18, 1 November 2019 (2019-11-01), pages 503 - 511, XP037317580, DOI: 10.1007/s11901-019-00494-w
See also references of EP 4061361A4
LIU HONGYAN; HOU JINLIN; ZHANG XIAOYONG: "Targeting cIAPs, a New Option for Functional Cure of Chronic Hepatitis B Infection?", VIROLOGICA SINICA., vol. 33, no. 5, 29 October 2018 (2018-10-29), pages 459 - 461, XP036635966, ISSN: 1674-0769, DOI: 10.1007/s12250-018-0062-x
WENTAO PAN, QIUYUN LUO, XIANGLEI YAN, LUPING YUAN, HANJIE YI, LIN ZHANG, BAOXIA LI, YUXIN ZHANG, JIAN SUN, MIAO-ZHEN QIU, DA-JUN Y: "A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity.", BIOCHEMICAL PHARMACOLOGY., vol. 154, 18 April 2018 (2018-04-18), pages 127 - 135, XP055502790, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.04.020
MAK LUNG-YI; SETO WAI-KAY; YUEN MAN-FUNG: "Future Therapies for Functional Cure of Chronic HBV: Review of Investigational Drugs in Phase 1 and 2 Development.", CURRENT HEPATOLOGY REPORTS., vol. 18, 1 November 2019 (2019-11-01), pages 503 - 511, XP037317580, DOI: 10.1007/s11901-019-00494-w
See also references of EP 4061361A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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