TREATMENT OF NEURODEGENERATIVE DISEASES BY TARGETING MIRNA

Title:

TREATMENT OF NEURODEGENERATIVE DISEASES BY TARGETING MIRNA

Document Type and Number:

WIPO Patent Application WO/2012/036433

Kind Code:

A3

Abstract:

The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases by targeting a specific miRNA. In addition, the present invention relates to a kit for diagnosing neurodegenerative diseases. A miR-206 target found in the present invention, which is highly expressed in both animal models of Alzheimer's disease and human brain samples, is a substantial treatment target selected without artifact errors. An antisense oligonucleotide of the present invention as an inhibitor for miR-206 suggests a successful result in treatment of neurodegenerative diseases by targeting miRNA. The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer's disease.

Inventors:

ROH JAE-KYU (KR)
LEE SANG KUN (KR)
KIM MAN HO (KR)
CHU KON (KR)
JUNG KEUN-HWA (KR)
LEE SOON-TAE (KR)

Application Number:

PCT/KR2011/006718

Publication Date:

June 28, 2012

Filing Date:

September 09, 2011

Export Citation:

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Assignee:

SNU R&DB FOUNDATION (KR)
ROH JAE-KYU (KR)
LEE SANG KUN (KR)
KIM MAN HO (KR)
CHU KON (KR)
JUNG KEUN-HWA (KR)
LEE SOON-TAE (KR)

International Classes:

A61K38/16; A61K31/7105; A61K31/711; A61P25/28

Foreign References:

US20090246136A1	2009-10-01
US20080313773A1	2008-12-18
US20080279846A1	2008-11-13

Other References: