Title:
TREATMENT OF PAIN WITH SEROTONIN-3 RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/2019/004292
Kind Code:
A1
Abstract:
Provided are a medicine for preventing or treating chronic pain and a method for preventing or treating chronic pain. A medicinal composition comprising a serotonin-3 receptor agonist, for example, a compound represented by formula (I) [wherein: m represents an integer of 1-4; and R1s are independently selected from a group consisting of a hydrogen atom, a halogen atom, a methyl group optionally substituted by 1-3 halogen atoms, a methoxy group optionally substituted by 1-3 halogen atoms and a methylthio group optionally substituted by 1-3 halogen atoms] or a pharmaceutically acceptable salt thereof is useful for preventing or treating chronic pain. The aforesaid medicinal composition is also effective for preventing or treating acute pain. Also provided is a method for screening a compound for preventing or treating chronic pain, said method comprising a step for measuring an agonistic activity on serotonin-3 receptors.
Inventors:
SHIMADA SHOICHI (JP)
YAMAMOTO YUKIKO (JP)
KONDO MAKOTO (JP)
YAMAMOTO YUKIKO (JP)
KONDO MAKOTO (JP)
Application Number:
PCT/JP2018/024404
Publication Date:
January 03, 2019
Filing Date:
June 27, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K45/00; A61K31/4545; A61P25/04; A61P43/00
Domestic Patent References:
| WO2016027757A1 | 2016-02-25 | |||
| WO2006021343A2 | 2006-03-02 |
Foreign References:
| JPH07145166A | 1995-06-06 | |||
| JPS5636481A | 1981-04-09 | |||
| JPH07145166A | 1995-06-06 |
Other References:
SASAKI, M. ET AL.: "Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 424, no. 1, 13 July 2001 (2001-07-13), pages 45 - 52, XP055663840, ISSN: 0014-2999, DOI: 10.1016/S0014-2999(01)01117-7
UCHIDA, KUNITOSHI ET AL.: " Antinociceptive action of fluvoxamine and antiallodynic action are achieved trough another serotonin receptor", PROGRAMS AND LECTURE ABSTRACTS OF COLLABORATIVE ANNUAL CONFERENCE OF THE 27TH JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY AND THE 35TH JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY, vol. 27, 2005, pages 253 (P-2-66), XP009518657
WEI GUO, KAN MIYOSHI, RONALD DUBNER, MING GU, MAN LI, JIAN LIU, JIALE YANG, SHIPING ZOU, KE REN, KOICHI NOGUCHI AND FENG WEI: "Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade", MOLECULAR PAIN, vol. 10, no. 1, 9 June 2014 (2014-06-09), pages 35-1 - 18, XP021189538, ISSN: 1744-8069, DOI: 10.1186/1744-8069-10-35
BRAVO-HERNANDEZ, M. ET AL.: "Role of perpheral and spinal 5-HT3 receptors in development and maintenance of formalin-induced long-term secondary allodynia and heperalgesia", PHARMACOL BIOCHEM BEHAVIOR, vol. 101, no. 2, 24 January 2012 (2012-01-24), pages 246 - 257, XP028460235, DOI: 10.1016/j.pbb.2012.01.013
"Multidisciplinary Pain Management: Core Curriculum for Education in Pain", SHINKO TRADING COMPANY LTD., PUBLICATION DEPARTMENT OF MEDICAL BOOKS, article "Pain and Brain", pages: 43 - 45
NAKAMURA Y ET AL., BIOCHEM BIOPHYS RES COMMUN., vol. 415, no. 2, 2011, pages 416 - 20
LUMMIS S ET AL., NEUROPHARMACOLOGY, vol. 73, 2013, pages 241 - 246
M NAKAMURA-KITAMURA ET AL., BRAIN RESEARCH, vol. 1406, 2011, pages 8 - 17
M NAKAMURA-KITAMURA ET AL., PAIN RESEARCH, vol. 27, 2012, pages 153 - 164
See also references of EP 3646886A4
UCHIDA, KUNITOSHI ET AL.: " Antinociceptive action of fluvoxamine and antiallodynic action are achieved trough another serotonin receptor", PROGRAMS AND LECTURE ABSTRACTS OF COLLABORATIVE ANNUAL CONFERENCE OF THE 27TH JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY AND THE 35TH JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY, vol. 27, 2005, pages 253 (P-2-66), XP009518657
WEI GUO, KAN MIYOSHI, RONALD DUBNER, MING GU, MAN LI, JIAN LIU, JIALE YANG, SHIPING ZOU, KE REN, KOICHI NOGUCHI AND FENG WEI: "Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade", MOLECULAR PAIN, vol. 10, no. 1, 9 June 2014 (2014-06-09), pages 35-1 - 18, XP021189538, ISSN: 1744-8069, DOI: 10.1186/1744-8069-10-35
BRAVO-HERNANDEZ, M. ET AL.: "Role of perpheral and spinal 5-HT3 receptors in development and maintenance of formalin-induced long-term secondary allodynia and heperalgesia", PHARMACOL BIOCHEM BEHAVIOR, vol. 101, no. 2, 24 January 2012 (2012-01-24), pages 246 - 257, XP028460235, DOI: 10.1016/j.pbb.2012.01.013
"Multidisciplinary Pain Management: Core Curriculum for Education in Pain", SHINKO TRADING COMPANY LTD., PUBLICATION DEPARTMENT OF MEDICAL BOOKS, article "Pain and Brain", pages: 43 - 45
NAKAMURA Y ET AL., BIOCHEM BIOPHYS RES COMMUN., vol. 415, no. 2, 2011, pages 416 - 20
LUMMIS S ET AL., NEUROPHARMACOLOGY, vol. 73, 2013, pages 241 - 246
M NAKAMURA-KITAMURA ET AL., BRAIN RESEARCH, vol. 1406, 2011, pages 8 - 17
M NAKAMURA-KITAMURA ET AL., PAIN RESEARCH, vol. 27, 2012, pages 153 - 164
See also references of EP 3646886A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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