Title:
TREATMENT OF PARTIAL GROWTH HORMONE INSENSITIVITY SYNDROME
Document Type and Number:
WIPO Patent Application WO1995027495
Kind Code:
A3
Abstract:
Methods for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, but not Laron syndrome, are described. One such method comprises administering a dose of greater than 0.3 mg/kg/week of growth hormone, preferably growth hormone with a native human sequence, with or without an N-terminal methionine, to the patient. The patient is characterized as having a height of less than about -2 standard deviations below normal for age and sex, serum levels of high-affinity growth hormone binding protein and IGF-I that are at least 2 standard deviations below normal levels, and a serum level of growth hormone that is at least normal. In another such method, the same patient population is treated with an effective amount of IGF-I alone or in combination with an amount of growth hormone that is effective in combination with IGF-I.
Inventors:
ATTIE KENNETH (US)
CARLSSON LENA M S (SE)
GESUNDHEIT NEIL (US)
GODDARD AUDREY (US)
CARLSSON LENA M S (SE)
GESUNDHEIT NEIL (US)
GODDARD AUDREY (US)
Application Number:
PCT/US1995/003731
Publication Date:
December 28, 1995
Filing Date:
March 24, 1995
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
A61K38/27; C12N15/09; A61K38/30; A61P3/00; A61P5/00; A61P43/00; C07K14/61; C07K14/65; C07K14/72; A61K38/00; (IPC1-7): A61K38/00; C07K14/65
Domestic Patent References:
| WO1991018621A1 | 1991-12-12 |
Other References:
K.A. ATTLE ET AL.: "Evidence for partial growth hormone insensitivity among patients with idiopathic short stature", J. PEDIATRICS, vol. 127, pages 244 - 250
N.J. HOPWOOD ET AL.: "Growth response of children with non-growth-deficiency and marked short stature during three years of growth hormone therapy", J. PEDIATRICS, vol. 123, pages 215 - 222
U. HEINRICH ET AL.: "Multicenter clinical trial with recombinant human growth hormone (GH) in GH-deficient and non-GH-deficient children", ACTA ENDOCRINOL., vol. 120, no. suppl. 1, pages 82 - 83
N.J. HOPWOOD ET AL.: "Growth response of children with non-growth-deficiency and marked short stature during three years of growth hormone therapy", J. PEDIATRICS, vol. 123, pages 215 - 222
U. HEINRICH ET AL.: "Multicenter clinical trial with recombinant human growth hormone (GH) in GH-deficient and non-GH-deficient children", ACTA ENDOCRINOL., vol. 120, no. suppl. 1, pages 82 - 83
Download PDF: