Title:
TREATMENT OR PROPHYLAXIS OF INSULIN-PRODUCING CELL GRAFT REJECTION
Document Type and Number:
WIPO Patent Application WO2002100148
Kind Code:
A3
Abstract:
A pharmaceutical combination comprising an accelerated lymphocyte homing agent in free form or in pharmaceutically acceptable salt form, and one or more compounds selected from the group consisting of an antibody to the IL-2 receptor, an immunosuppressive macrocylic lactone and a soluble human complement inhibitor is used to treat or prevent insulin-producing cell graft rejection.
Inventors:
LAKE PHILIP (US)
MULLON CLAUDY (US)
MULLON CLAUDY (US)
Application Number:
PCT/EP2002/006278
Publication Date:
April 22, 2004
Filing Date:
June 07, 2002
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS PHARMA GMBH (AT)
LAKE PHILIP (US)
MULLON CLAUDY (US)
NOVARTIS PHARMA GMBH (AT)
LAKE PHILIP (US)
MULLON CLAUDY (US)
International Classes:
A61K45/00; A61K31/137; A61K31/436; A61K38/00; A61K39/00; A61K39/395; A61K45/06; A61P3/10; A61P37/06; C07K16/28; (IPC1-7): A61P37/06; A61P3/10; A61K45/06; A61K31/66
Domestic Patent References:
| WO2002067915A1 | 2002-09-06 |
Foreign References:
| US6004565A | 1999-12-21 | |||
| US5952316A | 1999-09-14 |
Other References:
SHAPIRO A M ET AL: "Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.", THE NEW ENGLAND JOURNAL OF MEDICINE. UNITED STATES 27 JUL 2000, vol. 343, no. 4, 27 July 2000 (2000-07-27), pages 230 - 238, XP002220559, ISSN: 0028-4793
WHITE S A ET AL: "Human islet cell transplantation--future prospects.", DIABETIC MEDICINE: A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION. ENGLAND FEB 2001, vol. 18, no. 2, February 2001 (2001-02-01), pages 78 - 103, XP002220560, ISSN: 0742-3071
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; July 1998 (1998-07-01), YAMASAKI TORU ET AL: "Effect of a new immunosuppressive agent, FTY720, on survival of islet allografts.", XP002220561, Database accession no. PREV199800396576
WHITE S A ET AL: "Human islet cell transplantation--future prospects.", DIABETIC MEDICINE: A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION. ENGLAND FEB 2001, vol. 18, no. 2, February 2001 (2001-02-01), pages 78 - 103, XP002220560, ISSN: 0742-3071
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; July 1998 (1998-07-01), YAMASAKI TORU ET AL: "Effect of a new immunosuppressive agent, FTY720, on survival of islet allografts.", XP002220561, Database accession no. PREV199800396576
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