Title:
TREHALOSE COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL PRODUCT CONTAINING THE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/050178
Kind Code:
A1
Abstract:
A trehalose compound having high immunopotentiating activity and low toxicity. The trehalose compound is represented by formula (1). (In the formula, X and X' each represents a phenyl, a naphthyl, R1-CHR2- (wherein R1 and R2 each represents a C7-C21 alkyl group or the like) or the like; and n and n' each independently represents an integer of 0-3). The compound exhibits a high activating effect on macrophages and neutrophils.
Inventors:
NISHIZAWA MUGIO (JP)
IMAGAWA HIROSHI (JP)
YAMAMOTO HIROFUMI (JP)
SAKURAI JUN (JP)
ODA MASATAKA (JP)
IMAGAWA HIROSHI (JP)
YAMAMOTO HIROFUMI (JP)
SAKURAI JUN (JP)
ODA MASATAKA (JP)
Application Number:
PCT/JP2009/005650
Publication Date:
May 06, 2010
Filing Date:
October 27, 2009
Export Citation:
Assignee:
OTSUKA CHEMICAL CO LTD (JP)
NISHIZAWA MUGIO (JP)
IMAGAWA HIROSHI (JP)
YAMAMOTO HIROFUMI (JP)
SAKURAI JUN (JP)
ODA MASATAKA (JP)
NISHIZAWA MUGIO (JP)
IMAGAWA HIROSHI (JP)
YAMAMOTO HIROFUMI (JP)
SAKURAI JUN (JP)
ODA MASATAKA (JP)
International Classes:
C07H13/06; A61K31/7024; A61P31/00; A61P31/04; A61P35/00; A61P37/04; A61P39/02
Domestic Patent References:
| WO2007111214A1 | 2007-10-04 | |||
| WO2007111214A1 | 2007-10-04 | |||
| WO2008093700A1 | 2008-08-07 |
Foreign References:
| CA1202622A | 1986-04-01 | |||
| JPH11171727A | 1999-06-29 | |||
| JP2005330232A | 2005-12-02 |
Other References:
LIU JIA ET AL.: "Effect of Displacer Chemistry on Displacer Efficacy for a Sugar-Based Anion", EXCHANGE DISPLACER LIBRARY INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, vol. 45, no. 26, 2006, pages 9107 - 9114, XP008147128
NUMATA FUMIO ET AL.: "Lethal and adjuvant activities of cord factor (trehalose 6,6'- dimycolate) and synthetic analogs in mice", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 33, no. 10, 1985, pages 4544 - 4555, XP008111645
NISHIZAWA MUGIO ET AL.: "Efficient Syntheses of a Series of Trehalose Dimycolate (TDM)/ Trehalose Dicorynomycolate (TDCM) Analogues and Their Interleukin-6 Level Enhancement Activity in Mice Sera", JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 5, 2007, pages 1627 - 1633, XP002512853
NUMATA ET AL., CHEM. PHARM. BULL., vol. 33, no. 10, 1985, pages 4544 - 4555
"Protecting groups in Organic chemistry", 1991, JOHN WILEY & SONS INC.
CREGER, J. AM. CHEM. SOC., vol. 92, 1970, pages 1397 - 98
See also references of EP 2351764A4
NUMATA FUMIO ET AL.: "Lethal and adjuvant activities of cord factor (trehalose 6,6'- dimycolate) and synthetic analogs in mice", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 33, no. 10, 1985, pages 4544 - 4555, XP008111645
NISHIZAWA MUGIO ET AL.: "Efficient Syntheses of a Series of Trehalose Dimycolate (TDM)/ Trehalose Dicorynomycolate (TDCM) Analogues and Their Interleukin-6 Level Enhancement Activity in Mice Sera", JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 5, 2007, pages 1627 - 1633, XP002512853
NUMATA ET AL., CHEM. PHARM. BULL., vol. 33, no. 10, 1985, pages 4544 - 4555
"Protecting groups in Organic chemistry", 1991, JOHN WILEY & SONS INC.
CREGER, J. AM. CHEM. SOC., vol. 92, 1970, pages 1397 - 98
See also references of EP 2351764A4
Attorney, Agent or Firm:
NANJO, Masahiro et al. (JP)
Masahiro Nanjo (JP)
Masahiro Nanjo (JP)
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