Title:
TREPONEMA PALLIDUM TRIPLET ANTIGEN
Document Type and Number:
WIPO Patent Application WO/2012/097304
Kind Code:
A3
Abstract:
A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino acid leader sequence (tag 261) and human copper zinc superoxide dismutase (hSOD). This construct is optimized for in vitro diagnosis of syphilis infection. Plasmids containing DNA encoding the triplet antigen, host cells, production methods, detection methods, and kits are also disclosed.
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Inventors:
ZHENG JIAN (US)
YURA RENEE (US)
YANG JIANPING (US)
YURA RENEE (US)
YANG JIANPING (US)
Application Number:
PCT/US2012/021323
Publication Date:
September 13, 2012
Filing Date:
January 13, 2012
Export Citation:
Assignee:
ORTHO CLINICAL DIAGNOSTICS INC (US)
ZHENG JIAN (US)
YURA RENEE (US)
YANG JIANPING (US)
ZHENG JIAN (US)
YURA RENEE (US)
YANG JIANPING (US)
International Classes:
C12N15/63; C07H21/00; G01N33/53
Domestic Patent References:
| WO2006138324A2 | 2006-12-28 |
Foreign References:
| US20010002311A1 | 2001-05-31 |
Other References:
See also references of EP 2663642A4
Attorney, Agent or Firm:
JOHNSON, Philip, S. (One Johnson & Johnson PlazaNew Brunswick, NJ, US)
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