Title:
TRIALKYLAMINE DERIVATIVE AND AMELIORANT FOR DIGESTIVE TRACT MOVEMENT CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/1992/015553
Kind Code:
A1
Abstract:
A trialkylamine derivative represented by general formula (1) or a pharmacologically acceptable salt thereof, wherein R1 and R2 may be the same or different from each other and each represents lower alkyl; R3, R4 and R5 may be the same or different from one another and each represents hydrogen, lower alkyl, lower alkoxy, lower alkoxycarbonyl or halogen; R6 and R7 may the same or different from each other and each represents hydrogen or lower alkyl; R8 represents hydrogen, lower alkyl, lower alkoxy or halogen; X represents oxygen, sulfur, -CH=N- or -CH=CH-; Y represents oxygen, sulfur, methylene, =N-R11 (wherein R11 represents lower alkyl), =SO or =SO2; Z represents -OCO(CH2)p~ or -OCH2(CH2)p~ (wherein p represents a number of 0 to 4 and symbol ~ represents the linkage with a benzene ring; and m and n represent each a number of 0 to 3 and the sum of m and n is 3 or less, provided that the case where m is 0, n is 1 or 2, R1 and R2 represent each methyl, X represents -CH=CH-, Y represents -CH2-, and Z represents -O-CO~ is excluded). These compounds have an excellent activity of ameliorating digestive tract movement and hence are widely utilized in the treatment of digestive system diseases.
Inventors:
MUTO YOSHIAKI (JP)
ICHIKAWA HIROMI (JP)
OGURA KUNIYOSHI (JP)
CHAKI KYOJI (JP)
ICHIKAWA HIROMI (JP)
OGURA KUNIYOSHI (JP)
CHAKI KYOJI (JP)
Application Number:
PCT/JP1992/000270
Publication Date:
September 17, 1992
Filing Date:
March 06, 1992
Export Citation:
Assignee:
ZERIA PHARM CO LTD (JP)
International Classes:
C07C215/42; C07C217/52; C07C219/24; C07D215/06; C07D215/42; C07D307/79; C07D307/82; C07D311/58; C07D333/54; C07D333/78; C07D333/80; C07D335/06; (IPC1-7): A61K31/34; A61K31/35; A61K31/38; A61K31/435; A61K31/47; C07C217/52; C07C219/24; C07D215/42; C07D307/78; C07D311/68; C07D333/54; C07D333/80; C07D335/06; C07D491/048; C07D493/04; C07D495/04
Foreign References:
| CH637363A5 | 1983-07-29 | |||
| DE2803582A1 | 1979-08-02 | |||
| JPS5384955A | 1978-07-26 |
Other References:
CHEMICAL ABSTRACTS, Vol. 110, No. 15, Abstract No. 128064f, ABOUL-ENEIN, M.N. et al., "Esters of 1-(Dimethylamino)-1-Indanand 1,2,3,4-Tetrahydro-1-Naphthalene Methanol as Antispasmodics, Antiulcer Drugs, and Local Anaesthetics", Sci. Pharm., 56(4)243-50(1988).
J. Med. Chem., Vol. 16, No. 9, (1973), SARGES, REINHARD et al., "5,8-Disubstituted 1-Aminotetralins. Class of Compounds with a Novel Profile of Central Nervous System Activity", p. 1003-1011.
See also references of EP 0639557A4
J. Med. Chem., Vol. 16, No. 9, (1973), SARGES, REINHARD et al., "5,8-Disubstituted 1-Aminotetralins. Class of Compounds with a Novel Profile of Central Nervous System Activity", p. 1003-1011.
See also references of EP 0639557A4
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