Title:
TRIAMINE DERIVATIVE MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME
Document Type and Number:
WIPO Patent Application WO2002012166
Kind Code:
A3
Abstract:
The invention provides triamine derivative melanocortin receptor ligands of the formula (1), wherein R<1> to R<8> and n have the meanings provided herein. The invention further provides methods of using the ligands to alter or regulate the activitz of a melanocortin receptor.
Inventors:
WATSON-STRAUGHAN KAREN J (US)
GAHMAN TIMOTHY C (US)
QI MING (US)
HAMASHIN CHRISTA (US)
MACDONALD JAMES E (US)
GREEN MICHAEL J (US)
HOLME KEVIN R (US)
GRIFFITH MICHAEL C (US)
GAHMAN TIMOTHY C (US)
QI MING (US)
HAMASHIN CHRISTA (US)
MACDONALD JAMES E (US)
GREEN MICHAEL J (US)
HOLME KEVIN R (US)
GRIFFITH MICHAEL C (US)
Application Number:
PCT/EP2001/008417
Publication Date:
April 18, 2002
Filing Date:
July 20, 2001
Export Citation:
Assignee:
LION BIOSCIENCE AG (DE)
WATSON STRAUGHAN KAREN J (US)
GAHMAN TIMOTHY C (US)
QI MING (US)
HAMASHIN CHRISTA (US)
MACDONALD JAMES E (US)
GREEN MICHAEL J (US)
HOLME KEVIN R (US)
GRIFFITH MICHAEL C (US)
WATSON STRAUGHAN KAREN J (US)
GAHMAN TIMOTHY C (US)
QI MING (US)
HAMASHIN CHRISTA (US)
MACDONALD JAMES E (US)
GREEN MICHAEL J (US)
HOLME KEVIN R (US)
GRIFFITH MICHAEL C (US)
International Classes:
C07C211/27; C07C211/29; C07C215/18; C07C217/42; C07C217/62; C07C279/12; C07C323/25; C07C323/32; C07D207/12; C07D209/16; C07D211/26; C07D211/46; C07D217/14; C07D233/24; C07D233/64; C07D277/28; C07D295/092; C07D295/13; C07D307/14; C07D317/58; C07D333/20; C07D401/12; (IPC1-7): C07C279/12; C07C211/27; C07C211/29; C07D233/64; C07D209/20; A61K31/135; A61K31/4164; A61K31/404
Domestic Patent References:
| WO1999021571A1 | 1999-05-06 |
Other References:
J M OSTRECH ET AL: "Solid-phase synthesis of trisubstituted bicyclic guanidines via cyclization of reduced N-acylated dipeptides", JOURNAL OF ORGANIC CHEMISTRY., vol. 63, no. 24, 1998, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 8622 - 8623, XP002189498, ISSN: 0022-3263
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