Title:
TRIAZINE BENZIMIDAZOLE COMPOUNDS AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/207352
Kind Code:
A1
Abstract:
The present invention relates to the field of medicine, and in particular, to a compound as represented by formula I, pharmaceutically acceptable salts or esters, solvates, stereoisomers, tautomers, prodrugs, any crystalline form, metabolites thereof or a mixture thereof. The present invention further relates to a medical use of the compound as represented by formula I, pharmaceutically acceptable salts or esters, solvates, stereoisomers, tautomers, prodrugs, any crystalline form, metabolites thereof or the mixture thereof. The compound in the present invention has a strong inhibition effect on the activity of deubiquitinating enzyme USP7, has good pharmacokinetics property, and can be used to prevent or treat the cancer disease.
Inventors:
CHEN SHOUJUN (CN)
SONG SHUAI (CN)
JIANG XIAOLING (CN)
TANG ZUJIAN (CN)
TIAN QIANG (CN)
SONG HONGMEI (CN)
XUE TONGTONG (CN)
WANG JINGYI (CN)
SONG SHUAI (CN)
JIANG XIAOLING (CN)
TANG ZUJIAN (CN)
TIAN QIANG (CN)
SONG HONGMEI (CN)
XUE TONGTONG (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2020/083270
Publication Date:
October 15, 2020
Filing Date:
April 03, 2020
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P35/00
Domestic Patent References:
| WO2016109480A1 | 2016-07-07 | |||
| WO2018073602A1 | 2018-04-26 | |||
| WO2016126935A1 | 2016-08-11 |
Foreign References:
| CN107406451A | 2017-11-28 |
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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