Title:
TRIAZINE DIONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2022/105852
Kind Code:
A1
Abstract:
Provided are a triazine dione derivative, a preparation method therefor and an application thereof in medicine. Specifically, provided are a triazine dione derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative and a use thereof as a therapeutic agent, particularly a use in preparing a myosin inhibitor and a use in preparing a drug for treating hypertrophic cardiomyopathy (HCM) or heart diseases having pathophysiological features related to HCM.
Inventors:
ZHANG XIAOMIN (CN)
HU WEIMIN (CN)
FEI HONGBO (CN)
HE FENG (CN)
TAO WEIKANG (CN)
HU WEIMIN (CN)
FEI HONGBO (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2021/131642
Publication Date:
May 27, 2022
Filing Date:
November 19, 2021
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D251/40; A61K31/53; A61P9/04; A61P9/10; C07D407/02
Domestic Patent References:
| WO2020047447A1 | 2020-03-05 | |||
| WO2014205234A1 | 2014-12-24 | |||
| WO2020092208A1 | 2020-05-07 | |||
| WO2014205223A1 | 2014-12-24 | |||
| WO2014205234A1 | 2014-12-24 | |||
| WO2019028360A1 | 2019-02-07 | |||
| WO2020092208A1 | 2020-05-07 | |||
| WO2019023147A1 | 2019-01-31 | |||
| WO2017219948A1 | 2017-12-28 |
Foreign References:
| CN105473576A | 2016-04-06 | |||
| CN111116492A | 2020-05-08 | |||
| CN110698415A | 2020-01-17 | |||
| US20160176868A1 | 2016-06-23 | |||
| CN110698415A | 2020-01-17 |
Other References:
C. VAUGHAN TUOHY ET AL., EUROPEAN JOURNAL OF HEART FAILURE, vol. 22, 2020, pages 228 - 240
R ADHAKRISHNAN RAMARAJ, CARDIOLOGY IN REVIEW, vol. 16, no. 4, 2008, pages 172 - 180
NORBERT FREY ET AL., NATURE REVIEWS CARDIOLOGY, vol. 9, 2011, pages 91 - 100
M. SABATER-MOLINA ET AL., CLINICAL GENETICS, vol. 93, 14 March 2018 (2018-03-14)
ERIC M. GREEN ET AL., SCIENCE, vol. 351, no. 6273, 2016, pages 617 - 621
RUTH F. SOMMESE ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY SCIENCES, vol. 110, no. 31, 2013, pages 12607 - 12612
See also references of EP 4249474A4
R ADHAKRISHNAN RAMARAJ, CARDIOLOGY IN REVIEW, vol. 16, no. 4, 2008, pages 172 - 180
NORBERT FREY ET AL., NATURE REVIEWS CARDIOLOGY, vol. 9, 2011, pages 91 - 100
M. SABATER-MOLINA ET AL., CLINICAL GENETICS, vol. 93, 14 March 2018 (2018-03-14)
ERIC M. GREEN ET AL., SCIENCE, vol. 351, no. 6273, 2016, pages 617 - 621
RUTH F. SOMMESE ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY SCIENCES, vol. 110, no. 31, 2013, pages 12607 - 12612
See also references of EP 4249474A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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