Title:
TRIAZINE LIPIDS, LIPID SYNTHESIS, AND METHODS FOR INHIBITING CANONICAL NF KB TRANSCRIPTIONAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2024/015531
Kind Code:
A3
Abstract:
Triazine lipids and solid-phase synthesis methods for synthesizing triazine lipids are provided. Certain triazine lipids disclosed can inhibit canonical NFKB transcriptional activity and thus may be utilized in non-viral transfection vectors for administration with an immunostimulatory antigen to reduce reactogenic response invoked by the immunostimulatory antigen. Methods for inhibiting canonical NFKB transcriptional activity during an immune response are also provided.
Inventors:
VENDITTO VINCENT J (US)
NARDO PADRON DAVID (US)
MASUD ABDULLAH AL (US)
MORY JULIAN AGUSTIN (US)
NARDO PADRON DAVID (US)
MASUD ABDULLAH AL (US)
MORY JULIAN AGUSTIN (US)
Application Number:
PCT/US2023/027667
Publication Date:
March 14, 2024
Filing Date:
July 13, 2023
Export Citation:
Assignee:
UNIV KENTUCKY RES FOUND (US)
International Classes:
C07D251/54; A61K31/53; C07D251/58; A61K47/54; A61P43/00
Foreign References:
| US20210384524A1 | 2021-12-09 | |||
| US8921361B2 | 2014-12-30 |
Other References:
NARDO DAVID, AKERS CALEB M., CHEUNG NICHOLAS E., ISOM CIERRA M., SPAUDE JASON T., PACK DANIEL W., VENDITTO VINCENT J.: "Cyanuric chloride as the basis for compositionally diverse lipids", RSC ADVANCES, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 11, no. 40, 15 July 2021 (2021-07-15), GB , pages 24752 - 24761, XP093149080, ISSN: 2046-2069, DOI: 10.1039/D1RA02425F
PENNETTA CHIARA, BONO NINA, PONTI FEDERICA, BELLUCCI MARIA CRISTINA, VIANI FIORENZA, CANDIANI GABRIELE, VOLONTERIO ALESSANDRO: "Multifunctional Neomycin-Triazine-Based Cationic Lipids for Gene Delivery with Antibacterial Properties", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 32, no. 4, 21 April 2021 (2021-04-21), US , pages 690 - 701, XP093070295, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00616
DATABASE PubChem Compound 28 May 2009 (2009-05-28), ANONYMOUS : "2-N,4-N,4-N-trimethyl-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine ", XP093149077, retrieved from PubChem Database accession no. 27396213
PENNETTA CHIARA, BONO NINA, PONTI FEDERICA, BELLUCCI MARIA CRISTINA, VIANI FIORENZA, CANDIANI GABRIELE, VOLONTERIO ALESSANDRO: "Multifunctional Neomycin-Triazine-Based Cationic Lipids for Gene Delivery with Antibacterial Properties", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 32, no. 4, 21 April 2021 (2021-04-21), US , pages 690 - 701, XP093070295, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.0c00616
DATABASE PubChem Compound 28 May 2009 (2009-05-28), ANONYMOUS : "2-N,4-N,4-N-trimethyl-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine ", XP093149077, retrieved from PubChem Database accession no. 27396213
Attorney, Agent or Firm:
STEWART, Gary N. et al. (US)
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