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Title:
TRIAZINE SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/1981/003020
Kind Code:
A1
Abstract:
A process for the synthesis of substituted 1,3,5-triazine compounds of the general formula: (FORMULA) wherein R1 and R2, which may be the same or different, are selected from the group consisting of hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkylamino, dialkylamino, arylamino, alkyl-arylamino, alkylthio, arylthio, alkoxy and aryloxy (provided that R1 and R2 are not both halogen); and R3 is selected from the group consisting of halogen, alkylamino, dialkylamino, arylamino, alkyl-arylamino and N-heteroaryl; comprises reaction of a substituted halomethyleneiminium salt with a substituted N-cyanoamidine, N-cyanoguanidine, N-cyanocarbamimidate or N-cyanocarbamidothioate. Substituted 1,3,5-triazine compounds having fungal germination inhibition properties are also disclosed. The following compounds 1) 2-chloro-4-phenyl-1,3,5-triazine, 2) 2-chloro-4-phenoxymethyl-6-phenyl-1,3,5-triazine, 3) 2-N-methylphenylamino-4-phenyl-1,3,5-triazin, 4) 2-chloro-4-cyanomethyl-6-phenyl-1,3,5-triazine are also disclosed and claimed.

Inventors:
Harris R.
Application Number:
PCT/AU1981/000046
Publication Date:
October 29, 1981
Filing Date:
April 22, 1981
Export Citation:
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Assignee:
COMMW SCIENTIFIC IND RES ORG HARRIS R.
International Classes:
A01N43/66; C07D251/16; C07D251/20; C07D251/22; (IPC1-7): C07D251/16; C07D251/22; C07D405/04; C07D403/04
Foreign References:
US3203550A1965-08-31
US3154547A1964-10-27
DE1178437B
Other References:
Australian Journal of Chemistry, Vol 34, No. 3, issued 1981, March (CSIRO, Melbourne), R. HARRIS, "The Synthesis of Alkyl- and Aryl-Substituted 1,3,5,-Triazines", see pages 623-34
Chemische Berichte, Vol.109, issued 1976, REID et al, Uber Umsetzungen von Chlorformamidinen und N-Phenyl-Benzimidoylchlorid mit N-Cyanamidinen und 1-Cyanguanidin", see pages 2706 to 2715.
Journal of Heterocyclic Chemistry, Vol. 7, issued 1970, August, CRENSHAW et al. "A Synthesis of Isothiazoles and Pyrimidines via a Vilsmeier - Haack Reaction", see pages 871 to 873.
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Claims:
CLAIMS : ; ' "
1. A process for the synthesis of substituted 1,3,5 triazine compounds of the general formula I: wherein R 1 and R2, which may be the same or different, are selected from the group consisting of hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, . alkylamino, dialkylamino, arylamino, alkylarylamino, alkylthio, arylthio, alkoxy and aryloxy (provided that 1 2 3 R and R are not both halogen). ; and R is selected from the group consisting of halogen, alkylamino, dialkylamino, arylamino, alkylarylamino and Nheteroaryi; which comprises reaction of a halomethylene¬ iminium salt of. the general formula II: II 4 wherein R is selected from the group consisting of hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkylthio, arylthio, alkoxy and aryloxy; R and R , which may be the same or different, are selected from the group consisting of hydrogen, alkyl and aryl (provided that R and R are not both hydrogen) , 5 6 or R and R together with the nitrogen atom to which they are attached form a saturated heterocyclic ring; X is halogen; and Y is an anion; ,υ c: 2& with a compound of the general formula III: III wherein R is as defined above.
2. A process according to claim 1, wherein said reactio is carried ou;t in an inert organic solvent.
3. A process according to claim 2, wherein said inert organic solvent is selected from the group consisting of acetonitrile, benzene, chloroform and methylene chloride.
4. A process according to claim 1, wherein said reactio is carried out in an excess of phosphorus oxychloride as an inorganic solvent.
5. A process according to any one of claims 1 to 4, wherein said substituted 1,3,5triazine compounds are isolated from the reaction mixture by precipitation with water or by extraction into an organic solvent after addition of water.
6. A process according to claim 5, wherein said reactio mixture is neutralised prior to extraction of said substituted 1,3,5triazine compounds.
7. A process according to any one of claims 1 to 6, wherein said halomethyleneiminium salt of the general formula II is prepared by reaction of an amide of the general formula IV; or a dithiocarbamate of the general for wherein R 4, R5 and R6 are as defined in claim 1 with an acid halide.
8. A process according to claim 7 , wherein said acid halide is selected from POC1 J, POCl_.> αr'COCl 2,,.
9. A process according to claim 8, wherein said halomethyleneiminium salt is prepared in situ by reaction of an amide of the general formula IV as defined in claim 7 with phosphorus oxychloride, said phosphorus oxychloride being used in excess as solvent for the reaction.
10. A process according to claim 1, substantially as herein described with reference to Table 1 or in any one of Examples 1 to 10.
11. Substituted 1,3, 5triazine compounds of the general formula I as defined in claim 1, whenever prepared by a process according to any one of claims 1 to 10.
12. A substituted 1,3,5triazine Compound selected from the group consisting of 2chloro4phenyll,3,5 triazine, 2chloro4phenoxymethyl6ρhenyll,3,5 triazine, 2Nmethylphenylamino4phenyl1,3,5traizine and 2chloro4cyanomethyl6phenyll,3,5triazine.
Description:
_ " ι _

TRIA2IZTB SϊITTHΞSIS

This invention relates to a process for the synthesis of 1,3,5-triazine compounds, including in particular mono- or di-alkyl or -aryl substituted 1,3,5- triazines.

1,3, 5-Triazines are a class of heterocyclic compounds finding widespread use in many areas of chemical industry - notably as intermediates in plastics manufacture and as herbicides, in agriculture. Other triazines are used in disinfectants, algaecides, pharmaceuticals and explosives.

In practice, much of the industrial significance of triazines is confined to the symmetrical triazines including 2,4, 6-trihydroxy-s-triazine (cyanuric acid), 2,4,6-triamino-s-triazine (melamine) , and 2,4,6- trichloro-s-triazine (cyanuric chloride) and their derivatives, and the chemistry of these compounds has been widely studied", in part because of their ease of synthesis. Despite their intrinsic interest, however, mono- and di-alkyl or -aryl triazines have received relatively little attention. The primary reason for this appears to be the lack of availability of suitable general synthetic methods for this class of t iazine derivatives. For example, of the twelve or so methods presently available for the synthesis of this class of triazines few are of preparative value for triazines ' bearing two alkyl or aryl groups.

N-Cyanoamidines, potentially useful as startin materials for heterocyclic ring formation, have heretofo received scant attention, despite their ready availabili from imidates or amidines (K.R.Huffman and F.C.Schaefer, J. Org. Chem. , 28, 1812, (1963).), (J.T.Shaw and R.Ada J. Che . Eng. Data, 13, 142, (1968).) Their conversion to 1,3,5-triazines by condensation with amides, imidates amidines and nitriles under a variety of conditions was described by Huffman and Schaefer (supra) , but yields we disappointing (15-50%) . More recently, low yields of iminodihydrotriazines have been reported ( .Ried and N. Kothe, Chem. Ber., 109, 2706, (1976)) in the reaction of N-cyanoamidines with N-substituted chloroformamidines and imidoyl chlorides, and in one case a 1,3,5-triazine isolated. Attention has now been given to the reaction N-cyanoamidines, N-cyanoguanidines, N-cyanocarbamimidate or N-cyanocarbamidothioates with halomethyleneiminium salts, leading to the development of a novel synthesis o 1,3,5-triazines which is both versatile and convenient t carry out.

The novel synthesis of triazines from N-cyanoamidines, N-cyanoguanidines, N-cyanocarbamimidate or N-cyanocarbamidothioates and halomethyleneiminium sal in accordance with the present invention is of particula value since it can be successfully applied to the preparation of a wide range of triazine derivatives in which one or two of the substituents is an alkyl or an aryl substituent. Furthermore, by the appropriate choic of starting materials, triazines bearing a hydrogen substituent are also easily available.

The yields are generally high (up to 90%) and the starting materials readily available. The procedures are simple, and the conditions mild and readily amenable to large scale industrial synthesis. The method will, therefore, have wide application, and should open up the scope of triazine chemistry and further the application of triazines in chemical industry.

According to the present invention, there is provided a process for the synthesis of substituted 1,3,5- triazine compounds of the general formula I:

wherein R 1 and R2, which may be the same or different, are selected from the group consisting of hydrogen,, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkylamino, dialkylamj.no, arylamino, alkyl-arylamino, alkylth±o, arylthio, alkoxy and aryloxy (provided that

1 2 ' 3

R and R are not both halogen) ; and R is selected from the group consisting of halogen, alkylamino, dialkylamino, arylamino, alkyl-arylamino and N-heteroaryi; which comprises reaction of a halomethylene¬ iminium salt of the general formula II:

x ii

- C :-2

wherein R**~* i.s selected from the group consi•sting of hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkylthio, arylthio, alkoxy and aryloxy;

**_ fi R and R , which may be the same or different, are selected from the group consisting of hydrogen, alkyl

**! 6 and aryl (provided that R and R are not both hydrogen) , or R and R together with the nitrogen atom to which th are attached form a saturated heterocyclic ring; X ±_r halogen; and Y is ' an anion; with a compound of the general formula III:

NH, III wherein R is as defined above.

Compounds of the general formula III in which

R represents hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, o substituted heteroaryl are N-cyanoamidines. Where R represents alkylamino, dialkylamino, arylamino or alkyl-arylamino, the compounds III are N-cyanoguanidines.

Similarly, where R represents alkoxy or aryloxy, the ι compounds III are N-cyanocarbamimidates; and where R represents alkylthio or arylthio, the compounds III are

N-cyanocarbamidothioates.

In the above general formulae, . the alkyl groups preferably have 1 to 15 carbon atoms (including cycloalkyl groups of 4 to 8 carbon atoms) , and suitable aryl groups include phenyl and " naphthyl.

Suitable heteroaryl groups include 5 or 6 membered heterocyclic groups having one or more hetero atoms , (nitrogen, sulphur or oxygen) and include for example, indolyl and pyrazolyl groups. The substituents which may be present on the alkyl, aryl or heteroaryl groups include one or more substituents selected from the group consisting of halo (particularly chloro or bromo) , alkyl (particularly lower alkyl having from 1 to 6 carbon atoms) , alkoxy (particularly lower alkoxy having from 1 to 6 carbon atoms) , alkylthio (particularly lower alkylthio having from 1 to 6 carbon atoms) , aryl (particularly phenyl) , aryloxy (particularly phenoxy) , arylthio (particularly phenylthio) , cyano, nitro, alkoxycarbonyl (particularly lower alkoxycarbonyl) , amino and dialkyl- amino (particularly di (lower alkyl) amino) . Halogen groups in the general formulae include bromo and, more preferably, chloro, whilst the anion represented by Y may be a bromide or chloride ion or an inorganic anion such as 0P0C1 2 ~.

The preferred -procedure for the synthesis of this invention is to bring together the compounds of formula II and formula III in a suitable inert organic solvent. The following solvents have been found to be suitable: benzene, chloroform, methylene chloride, acetonitrile; the preferred solvent in most reactions being acetonitrile. Alternatively, phosphorus oxyσhloride may be used in excess as an inorganic solvent.

The reaction mixture is then maintained at a suitable temperature (preferably between 0 C and 100 C) for an appropriate length of time C or example, from 15 min. to 6 days), then the 1,3,5-triazine is isolated by precipitation with, water or extraction into an organic solvent after addition of water to the reaction mixture. In some cases neutralisation with sodium hydroxide solution is desirable to liberate all the triazine products from their salts. In cases when a mixture of triazines results, separation and purificat on of the components of th.e mixture can be effected by chromatograph .

As an illustrative example of the process of t present invention, reaction of the chloromethyleneiminiu salt CN,N-dimethylbenzamide-POCl_ complex) with N-cyanpbenzamidine in acetonitrile at room temperature gives 2-chloro-4, 6-diphenyl-l,3,5-triazine in 70% yield Extension of the reaction to other chloromethyleneiminiu salts, conveniently prepared in situ from N-substituted amides and POCl or PCI-./ gives the appropriately substituted 1,3,5-triazine in good yield. Other N-cyanoamidines react analogously, and examples of triazines. so prepared are given in Table 1. It is found that in addition to chlorotriazines, small quantities of aminotriazines are sometimes formed, and that these beco major products when N-arylamides are used as ' starting material Csee Table 1) . These aminotriazines may be formed in a secondary reaction between initially formed chlorotriazines and amines liberated during the cyclisation.

The choice of conditions for the triazine synthesis is governed principally by the reactivity of the amide precursor of the chloromethyleneiminium salt : reactive amides such as dimethylformamide and dimethyl- . acetamide can be reacted with POCl - in acetonitrile or other inert solvent at room temperature or below whereas unreactive amides such as benzanilide require PCI -." as the acid chloride component . As previously described in many cases POCl.. can be used in excess as solvent for the reaction .

The N-cyanoamidines used in this synthesis are available by known methods from nitrile precursors via amidine or iriinoether intermediates (Huffman and Schaefer, supra, Shaw and Mams, supra) . The N-cyanoguanidines, N-^yanocarbamimidates and N-cyanccarbait diothioates may be prepared by known methods also (E.Grigat and R.Putter, post. ; E.Allenstein, and R.Fuchs, Chem.Ber. , 100, 2604 (1967) ; D.W.Kaiser, and D.Holm-Hansen, U.S. Patent 2697727) .

The halomethyleneiminium salts may be prepared by known methods from amide and dithiocarbamate precursors

- for a discussion on their preparation , see "Advances in Organic Chemistry" , Vol . 9 , parts 1 and 2 (H. Boh e and H. G . Viehe, editors) , " Inter science" (John Wiley and Co . , N . Y. ) , 1976-1979 . These methods may be illustrated schematically as follows :

V

(Dithiocarbamate)

It has been found advantageous to prepare many of the halomethyleneiminium salts in ' situ from the appropriate amide precursor by reactionwith an acid halide such as PO ' Cl , PC1 5 or. COC1 in a suitable solvent prior to the addition of the compound of the general formula III. When phosphorus oxyσhloride is used as the acid halide component it may sometimes be used in excess as solvent for the reaction.

Alkylthiochloromethyleneiminium salts (II,

4 R = alkylthio) may also be prepared in situ from the appropriate dithiocarbamate and phosgene (Eilingsfeld and Mobius, Chem. Ber. , 98, 1293, (1965)) and subsequent reacted with, a compound of the general formula III in acetonitrile or phosphorus oxychloride as solvent.

Dichloromethyleneiminium salts may be generate from S,N,N-trialkyldithi.ocarbamates by reaction with chlorine. It is known that dichloromethyleneiminium sal may be reacted with activated aromatic or heterocyclic compounds, phenols or thiophenols to produce other reactive methyleneiminium salts in which one of the chlorines is displaced by an aryl, heteroaryl, aryloxy o arylthio group. This is shown schematically below, usin dichloromethylenedimethyli inium chloride as example:

(see "Advances in Organic Chemistry" Vol.9 Pares 1 and 2 supra) .

The derived reagents VI are of course chloro¬ methyleneiminium salts of the class II described earlier and may be generated in situ and used in the new triazine synthesis as described above. By way of example, reaction of dichloromethylenedimethyliminium chloride with one equivalent of N,N-dimethylaniline for 15 min. in acetonitrile at reflux generates reagent VI where R = P-dImethylaminoph.enyl. Addition of N-cyanobenzamidine and further reflux gives, after work-up, 2- (p-dimethyl- aminophenyl) -4-phenyl-6-chloro-l,3, 5-triazine.

Similarly, reaction of dichloromethylenedimethyliminium chloride with one equivalent of phenol in methylene chloride generates reagent VI where R = phenoxy, and further reaction with cyanobenzamidine gives 2-chloro-4- phenoxy-6-phenyl-1, 3, 5-triazine.

The reaction of the present invention therefore represents a facile route to diversely substituted 1,3,5- triazines, many of which are not otherwise readily accessible. In addition, the novel synthesis enables access to certain compounds of the general formula I above which are themselves novel.

Table 1 hereinafter illustrates the preparation of a number of different substituted 1,3,5-triazine compounds in accordance with this invention:

TABLE 1

Chlpromethylene- N-cyano- Solvent/ Yield m.p. Mass

1,3,5-Triazine Molecular imln£.um salt amidine Conditions b (%) (°C) formula Spectrum'

R° R" R 1 ' I R 1 R 2 R or Lit.m.p.

Ph Me Me OPOC1, Ph MeCNΛh a Ph Ph Cl 70 139 138-9 267 reflux

H Me Me 0P0C1,. Ph MeCN/15 min. b Ph H Cl 56 86-87 C 9 H 6 C1 3 191 25°. . (191.6)

Me Me Me 0P0C1 Ph C H /18h c Ph Me Cl 81 75 6 6 75.5-76.5 205

25° d Ph Me NMe 5 63 214

C 12 H 14 N 4 (214.3)

Me H Ph 0P0C1, Ph MeCN/1 h c Ph Me Cl 4 75 reflux e Ph Me NHPh 84 133 262

16 14 4 (262.3)

Ph H Ph Cl Ph MeCN/1 h a Ph Ph Cl 48 139 reflux f Ph Ph NHPh 25 155 155 324

Indol-3-yl Me Me OPOCl,. Ph • MeCN/6 days g Ph Indol- Cl 47 195 306 25° 3ryl C 17 H 11 C1N 4 (306.75)

Cl Me Me Cl Ph POCl /l5 min. h Ph Me N Cl 85 105 C reflux 1..1H1.1.C1N4. 234

(234.7)

MeS Me Me Cl Ph POCl / h i Ph MeS Cl 56 89 237 reflux C 10 H 8 C1N 3 S (237.7) — Ph Me Me OPOC1 Me MeCN/.h c Me Ph Cl 49 75 | ^ \ \ reflu ' d Me Ph NMe. 5 63

TABLE 1 (cont'd)

Chloromethylene¬ N-cyano- Solvent/ Yield m.p.

1,3,5-Triazine Molecular Mass iminium salt amidine Conditions (%) <°C) formula Spectrum

•4 R 5 R 6 R 1 I R 1 R < R ,3 or Lit.m.p.

Ph Me Me 0P0C1 2 C~- κ 2 MeCN/1 h. j C1CH Ph Cl 88 86-87 239 reflux C 10 H 7 C1 2 N 2 (240.1)

Ph CH -(CH 1 - Cl Ph MeCN/48h k Ph Ph CH (CH 2 ) 4 64 183-184 392 reflux C 26 H 24 N 4 (392.48)

PhOCH, Et Et OPOCl Ph MeCNΛh 1 Ph PhOCH Cl 67 81 C 16 H 12 C1 3 0 297 .-reflux

(297.74) oToluyl Me Me OPOCl Ph POCl /lh m Ph oToluyl Cl 80 72-7 C 1 c H η _N_Cl 281 reflux 16 12 3

( 281. 74 )

CH (CH ) • H cyclo- 0P0C1 2 Ph MeCN/. n Ph. CH cH 2 } ιo C1 87 44-5 345 hexyl reflux C 20 H 28 C1N 3 (345.5)

PhOT Me Me OPOCl Ph MeCN/ϊjh o Ph PhCH Cl 14 oil 281 reflux i C 16 H 12 C1N 3 (281.74)

H Me Ph OPOCl Ph MeCN/^h p Ph H N(Me)Ph 67 80 262 reflux 16 14 4 (262.30)

TABLE 1 (cont ' d)

Chloromethylene- N-cyano- Solvent/ Yield m.p. Molecular Mass iminiuπ) sa,lt 1,3,5-Triazine .amidine Conditions (%) <°C> formula Spectrum

R R° R 1 I R 1 R 2 . B or Lit.m.p.

PhO Me Me Cl Ph CH_Cl 2 /2h s Ph PhO .Cl 53 103 283

• C 15 H 10 C1N 3° reflux (283.71)

Ph Me Me OPOCl PhO MeCN/lh s PhO Ph . .Cl 71 .103- C, _H, „C1N_0 283 15 10 3 reflux

(283.71)

© (CH ) )- OPOCl MeS .MeCN/lh t MeS <^>- , .-.Cl 62 92-3 C_H,C1N_0S 227 8 6 3 reflux

(227.61) pMeC_H„ Me Me OPOCl • EtO MeCN/^h u EtO pMeC,H Λ Cl 80 78 ' 249 6 4 6 4 reflux C 12 H 12 C1N 3° (249.70)

Ph Me Me OPOCl Cl CH 2 Cl 2 /18h V Cl Ph Cl 58 118-9 119-120 Rm. Tem .

Ph Me Me Br Ph CH Cl /18h w Ph Ph Br 58 115 C,_ H ^ BrN., 311 15 10 3 R . Temp. (312.17)

Ph Me Me Cl COOEt .CH 2 Cl 2 /18h x COOEt Ph •' . Cl 41 70-71 263

C 12 H 19 C1N 3°2 Rm. Tem . (263.5)

Microanalyses were in' satisfactory agreement with calculated values (maximum deviation C ± 0.42,

H ± 0.27, N ± 0.32) .

35 79 Mass spectra recorded on A.E.I. MS-9 instrument; molecular ions containing Cl or Br are shown,

1,3, 5-triazines which can be prepared in accordance with the present invention have been found to exhibit fungal germination inhibition properties as shown in Table 2.

TABLE 2

Inhibition of Germination of Tilletea Foetida by

1,3 ,5-Triazines

1,3,5-Triazines Spore Germination inhibition at 10 ppm (%)

2-chloro-4-phenyl 100

2-chloro-4-phenoxymethyl-6-phenyl 100 2-N-methylphenylamino-4-phenyl 100

2-chloro-4-cyanomethyl-6-phenyl 100

The process of the present invention is further illustrated by the following specific examples:

EXAMPLE 1

2-Chloro-4, 6-diphenyl-l,3,5-triazine (la)

N,N-Dimethylbenzamide ( . 1.49 g, 10 mmol) , is heated with POCl., Cl ml) on a steam bath at 100 for 5 min. The resulting complex is dissolved in acetonitrile (10 ml) and a solution of N-cyanobenzamidine (1.45 g, 10 mmol) in acetonitrile (20 ml) is added. After several minutes the triazine begins to separate; after 30 min water is added to complete the precipitation and the product is collected, washed with water and recrystallized from ethanol-water; yield: 1.8 g C70%) ; m.p. 139° (lit., 138-9°)

EXAMPLE 2

2-Anilino-4-methyl-6-phenyl-l,3 ,5-triazine (le) :

N-Cyanobenzamidine (1.45 g, 10 mmol), acetanilide (1.35 g, 10 mmol) and P0C1 3 (1 ml) are refluxed in acetonitrile (20 ml) for 1 h. The hydro-._ chloride of (le) precipitates as a pale yellow crystalli solid, m.p. 198-204°, and is collected after the mixture has been allowed to stand at room temperature over night (yield 2.5 g, 84%) . The free triazine is obtained as colorless flat needles, m.p. 133 and is identical (m.p., mixed m.p., nmr, ir and mass spectrum) with samples prepared by reaction of (Ic) with aniline in acetonitril (reflux, 30 min) and from the reaction of N-phenyl- benzimidoyl chloride and N-cyanoacetamidine according to ' Ried and Kothe (Chem. Ber. , 109, 27,06, (1976) .) The benzene-soluble fraction from the reaction mixture is washed with dilute ammonia, dried (MgSO.) and chromato- graphed on silica gel (Merck 70-30 mesh ASTM) eluting wi benzene. The first fractions from the column contain (Ic (0.075 g, 3.7%), m.p. 75° (lit. 75 -5-76.5°) .

EXAMPLE 3

2-Chloro-4-phenyl-6-methylthio-l,3, 5-triazine (li)

S,N,N-Trimethyldithiocarbamate (1.35 g, 10 mmol is dissolved in toluene (10 ml) containing phosgene (20%, w/v) and the solution kept at room temperature protected from moisture for 1 hr.- The solvent and excess phosgene are evaporated in vacuo and to the residue is added POCl, (10 ml) and N-cyanobenzamidine (1.45 g) . The mixture is refluxed for 30 min and poured into water. The product is extracted into benzene and purified by chromatography on silica gel eluting with benzene; the first fractions contain the methylthiotriazine (li) (1.3. g, 56%) , m.p. 89

- -

EXAMPLE 4

2-chloro-4-ρhenyl-6-(p-dimethylaminophenyl) -1,3, 5-triazine

(Iq) :

Dichloromethylene dimethyliminium chloride (1.9g) was suspended in acetonitrile (20 ml) and N,N-dimethyl- aniline (1.3 ml) added. The mixture was refluxed until all solids had dissolved (15 min.) then N-cyanobenzamidine (1.45g) added. The mixture was refluxed a further lJ_?h and poured into water. An orange solid precipitated and after adjusting the pH to 5 with solid sodium acetate the mixture was allowed to stand at room temperature overnight. The solid was collected and recrystallised from ethanol to give the dimethylaminophenyltriazine (l.lg 35%) as orange needles, m.p. 169-70 .

E -___X__--A-___M___P-.--L__-_E_-------5-— »

2-chloro-4-phenyl-6-undecyl-l,3,5-triazine (In) :

N-cyclohexyl dodecanamide (1.4g), phosphorous oxychloride (0.5 ml) and N-cyanobenzamidine (0.80g) were heated under reflux in acetonitrile (20 ml) for %h . The mixture was poured into water and the solid collected. The product was purified by passage of its solution in ethylene chloride through a short column of silica gel; removal of the solvent from the eluate gave a pale tan oil which crystallised. Yield 1.5 g 87%, m.p. 44-45 .

EXAMPLE 6

2-chloro-4-phenoxy -6- phenyl-1,3,5-triazine Cls) . * ;

METHOD A: Dichloromethylenedimethyliminium chloride (1.8g) was added to a stirred solution of phenol (Ig) in dry dichloromethane (50 ml) . After 15 min a clear solution had resulted, to which was added N-cyanobenzamidine (1.45g) .

The mixture was heated under reflux protected from moisture for 2 h, the solvent evaporated and the residue recrystallised from aqueous ethanol giving the phenoxy- triazine (Is) as colorless plates (1.8g, 53%) , m.p. 103

METHOD B: Phosphorous oxychloride (0.4 ml) was added to N,N-dimethylbenzamide (0*.6. g) dissolved in acetonitrile (10 ml) . After 15 min at room temperature, N-cyano-O- phenylcarbamimidate (E.Grigat and R.Putter Chem. Ber. , 9 2619, (1965)1 (0.65 g) was added and the mixture heated under reflux protected from moisture for 1 h. Water ClOO ml) was added and the precipitate collected after 1 and recrystallised from aqueous ethanol. The phenoxy- triazine ( 0.8 g, 71%) had m.p. 103 and was identical (nmr, mass spec, mixed m.p.) . to that obtained by method

EXAMPLE 7

2-chloro-4 (.2 -furyl) -6-methylthio-1,3,5-triazine (It)

Phosphorous oxychloride (1 ml) was added to a solution o 2-furfuroylpyrrolidine (1.65 g) in acetonitrile (20 ml) . After 15 min N-cyano-S-methylcarbamimidothioate (R.W.Turne Synthesis, 0-975) , 332} (1.2 g)* was added and the mixture heated under reflux protected from moisture for and then poured into water (100 ml) . The precipitate wa collected after 1 h and recrystallised from petroleum et (bp 60-80 ) to give the methylthiotriazine Clt) as colorless needles (1.4 g, .62%) , m.p. 92-93°.

EXAMPLE 8

2-chloro-4-ethoxy-6-p-tolyl-l, 3, 5-triazine (Iu) :

N,N-dimethyl-p-toluamide (1.65 g) and phosphorous oxychloride (1 ml) were dissolved in acetonitrile (20 ml) . To the solution was added N-cyano-O-ethyl carbamimidate (1.13 g) and the mixture heated under reflux protected from moisture for J_ h. Water (100 ml) was added and the precipitated product collected after 1 h at 0 C and recrystallised from aqueous ethanol to give the ethoxy- triazine (Iu) as colorless needles (2 g, 80%) , m.p. 78 .

EXAMPLE 9

2,4-Dichloro-6-phenyl-l,3 ,5-triazine (Iv) :

N,N-Dimethylbenzamide (1.5 g) and phosphorous oxychloride (1 ml) were dissolved in methylene chloride (20 ml) and the mixture kept at room temperature for 15 min. N-Cyanochloroformamidine (1.1 g) (E. Allenstein, Z. Anorg. Allgem. Chem., 322, 265 (1963)) was added and the mixture stirred at room temperature overnight protected from moisture. The mixture was shaken with water (100 ml) and the organic phase separated, dried, concentrated in vacuo and applied to a column of silica gel (2 x 15 cm) . Elution with benzene gave the dichloro- triazine (1.3 g, 58%) which crystallised from ethanol as colorless needles, m.p. 118-119° (lit 120°) .

EXAMPLE 10 2-Bromo-4 ,6-diphenyl-l,3, 5-triazine (Iw) :

N,N-Dimethylbenzamide (1.5 g) was added to a stirred solution of phosphorous tribromide (2 ml) and bromine (1 ml) in methylene chloride (50 ml) and the mixture stirred protected from moisture at room temperature for 1 h. Cyclohexene (2 ml) was added to discharge the

bromine colour, followed by N-cyanobenzamidine (1.45 g) . The mixture was protected from moisture and stirred overnight. Water (100 ml) was added and stirring continued for 5 min. The organic layer was separated, dried and the solvent removed in vacuo. The product wa purified by passage of its solution in-si-ethylene chlorid through a short column of silica gel. Evaporation of th eluate and recrystallisation of the ~ residue from ethanol gave the bromotriazine (Iw) as colorless fine needles (1.75 g, 58%), m.p. 155°.

It will be appreciated by those skilled in the art that modifications and variations may be made to the specific details included herein without departing from the broad teaching of the present invention and the invention thus encompasses all such modifications and variations.