Title:
TRIAZINYLMETHYLCYCLOALKYLCARBOXYLIC ACID DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/253270
Kind Code:
A1
Abstract:
A substituted triazinylmethylcycloalkylcarboxylic acid derivative having a structure as shown in formula (I). In addition, further disclosed are a pharmaceutically acceptable salt, a stereoisomer, a pharmaceutical composition and the use of the derivative. The compound has significant P2X3 inhibitory activity and selectivity, and is high in application value.
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Inventors:
HU BIN (CN)
ZHU JINGFENG (CN)
YANG WEN (CN)
XIE JING (CN)
SHI XIAOYONG (CN)
ZHANG KAI (CN)
ZHAO ZHIMING (CN)
KAN CHAO (CN)
ZHU JINGFENG (CN)
YANG WEN (CN)
XIE JING (CN)
SHI XIAOYONG (CN)
ZHANG KAI (CN)
ZHAO ZHIMING (CN)
KAN CHAO (CN)
Application Number:
PCT/CN2022/096597
Publication Date:
December 08, 2022
Filing Date:
June 01, 2022
Export Citation:
Assignee:
SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN)
YANGTZE RIVER PHARM GROUP CO (CN)
YANGTZE RIVER PHARM GROUP CO (CN)
International Classes:
C07D251/46; A61K31/53; A61P25/00; A61P29/00; A61P43/00
Domestic Patent References:
| WO2017204316A1 | 2017-11-30 |
Foreign References:
| CN102395571A | 2012-03-28 | |||
| CN103153968A | 2013-06-12 |
Other References:
LEWIS ET AL., NATURE, vol. 377, 1995, pages 432 - 435
GARCIA-GUZMAN ET AL., BRAINRES. MOL. BRAINRES., vol. 47, 1997, pages 59 - 66
COCKAYNE ET AL., NATURE, vol. 407, 2000, pages 1011 - 1015
JARVIS ET AL., PNAS, vol. 99, 2002, pages 17179 - 17184
ZHONG ET AL., NEUROSCIENCE, vol. 120, 2003, pages 667 - 675
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
no. 1342511-06-1
GARCIA-GUZMAN ET AL., BRAINRES. MOL. BRAINRES., vol. 47, 1997, pages 59 - 66
COCKAYNE ET AL., NATURE, vol. 407, 2000, pages 1011 - 1015
JARVIS ET AL., PNAS, vol. 99, 2002, pages 17179 - 17184
ZHONG ET AL., NEUROSCIENCE, vol. 120, 2003, pages 667 - 675
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
no. 1342511-06-1
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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