Title:
TRIAZOLAMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/185752
Kind Code:
A1
Abstract:
Disclosed in the present invention are a triazolamide compound, a preparation method therefor, and a use thereof. Specifically, disclosed are a triazolamide compound as shown in formula I or a pharmaceutically acceptable salt thereof, and a use thereof in the preparation of a drug for treating and/or preventing HDAC-related diseases. The diseases may be cancers.
Inventors:
CHENG JIANJUN (CN)
XIE CHENGYING (CN)
YAN WENZHONG (CN)
YANG KEXIN (CN)
XIE CHENGYING (CN)
YAN WENZHONG (CN)
YANG KEXIN (CN)
Application Number:
PCT/CN2023/084136
Publication Date:
October 05, 2023
Filing Date:
March 27, 2023
Export Citation:
Assignee:
UNIV SHANGHAI TECH (CN)
SHANGHAI INSTITUTE OF MAT MEDICA CHINESE ACADEMY OF SCIENCES (CN)
LINGANG LABORATORY (CN)
SHANGHAI INSTITUTE OF MAT MEDICA CHINESE ACADEMY OF SCIENCES (CN)
LINGANG LABORATORY (CN)
International Classes:
C07D249/06; A61K31/16; A61K31/4192; A61K31/4439; A61P35/00; C07D249/04; C07D401/04; C07D403/04; C07D405/04
Domestic Patent References:
| WO2003087066A1 | 2003-10-23 |
Foreign References:
| CN106916101A | 2017-07-04 | |||
| CN113387938A | 2021-09-14 | |||
| CN102648177A | 2012-08-22 | |||
| CN103420917A | 2013-12-04 |
Other References:
DATABASE Registry 25 March 2018 (2018-03-25), ANONYMOUS: "2H-1,2,3-Triazole-4-carboxamide, 2-(3-chlorophenyl)-N-[[4- [(hydroxyamino)carbonyl]phenyl]methyl]-5-methyl- (CA INDEX NAME)", XP093097388, retrieved from STNext Database accession no. 2198332-99-7
DATABASE Registry 30 March 2018 (2018-03-30), ANONYMOUS: "2H-1,2,3-Triazole-4-carboxamide, 2-(2,4-dimethylphenyl)-N-[[4- [(hydroxyamino)carbonyl]phenyl]methyl]-5-methyl- (CA INDEX NAME)", XP093097390, retrieved from STNext Database accession no. 2202242-78-0
SUN NAN, YANG KEXIN, YAN WENZHONG, YAO MINGYUE, YU CHENGCHENG, DUAN WENWEN, GU XIAOKE, GUO DONG, JIANG HUALIANG, XIE CHENGYING, CH: "Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 66, no. 7, 13 April 2023 (2023-04-13), US , pages 4802 - 4826, XP093097374, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.2c01985
DATABASE Registry 30 March 2018 (2018-03-30), ANONYMOUS: "2H-1,2,3-Triazole-4-carboxamide, 2-(2,4-dimethylphenyl)-N-[[4- [(hydroxyamino)carbonyl]phenyl]methyl]-5-methyl- (CA INDEX NAME)", XP093097390, retrieved from STNext Database accession no. 2202242-78-0
SUN NAN, YANG KEXIN, YAN WENZHONG, YAO MINGYUE, YU CHENGCHENG, DUAN WENWEN, GU XIAOKE, GUO DONG, JIANG HUALIANG, XIE CHENGYING, CH: "Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 66, no. 7, 13 April 2023 (2023-04-13), US , pages 4802 - 4826, XP093097374, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.2c01985
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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