Title:
TRIAZOLE ANTIBACTERIAL DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/149359
Kind Code:
A1
Abstract:
The present invention provides a triazole antibacterial derivative and a pharmaceutical composition and a use thereof, and in particular relates to a compound represented by the following formula (I), and a racemate, a stereoisomer, a tautomer, and a nitrogen oxide thereof or their pharmaceutically acceptable salts, as shown in formula (I). The compound of the present invention has a desirable water solubility and can be formulated into an injection for use without adding a cosolvent having a potential safety risk (such as hydroxypropyl-β-cyclodextrin and sulfobutylether-β-cyclodextrin), facilitating drug administration for patients, and greatly improving clinical safety. The drug can be used even by patients with moderate or severe renal impairment, thereby expanding the application scope of the drug.
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Inventors:
TANG HONGWEI (CN)
LOU JUN (CN)
YU PENGGAO (CN)
LIU LI (CN)
ZHENG ANXIAO (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
LOU JUN (CN)
YU PENGGAO (CN)
LIU LI (CN)
ZHENG ANXIAO (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2018/075862
Publication Date:
August 23, 2018
Filing Date:
February 08, 2018
Export Citation:
Assignee:
WUHAN LL SCIENCE AND TECH DEVELOPMENT CO LTD (CN)
WUHAN QR PHARMACEUTICALS CO LTD (CN)
WUHAN QR PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K31/506; C07D401/14; A61K31/675; A61K31/7064; A61P31/10; C07D403/06; C07F9/6558; C07H1/00; C07H13/04
Domestic Patent References:
| WO2013130660A1 | 2013-09-06 | |||
| WO2008106860A1 | 2008-09-12 | |||
| WO2015112801A1 | 2015-07-30 |
Foreign References:
| CN106467519A | 2017-03-01 | |||
| CN104230894A | 2014-12-24 | |||
| CN1387529A | 2002-12-25 | |||
| CN101391985A | 2009-03-25 | |||
| CN1251098A | 2000-04-19 | |||
| US6235728B1 | 2001-05-22 | |||
| US6300353B1 | 2001-10-09 | |||
| CN1261287A | 2000-07-26 | |||
| CN201710087041A | 2017-02-17 | |||
| CN103626825A | 2014-03-12 |
Other References:
ZHANG YIYI ET AL.: "Synthesis of Novel Fluconazoliums and Their Evaluation for Antibacterial and Antifungal Activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 9, 8 July 2011 (2011-07-08), pages 4391 - 4402, XP028278342, ISSN: 0223-5234
RYBAK JEFFREY M. ET AL.: "Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent", PHARMACOTHERAPY, vol. 35, no. 11, 31 December 2015 (2015-12-31), pages 1037 - 1051, XP055535100, ISSN: 1875-9114
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 190447-69-9
JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 98, 2004, pages 1933 - 1946
BIOORG. MED. CHEM. LETT., vol. 15, 2005, pages 3934 - 3941
CHEM. ASIAN J, vol. 9, 2014, pages 739 - 743
MINCH, BRITT A. ET AL.: "Octakis(2-benzyloxyethylsulfanyl) Copper (II) Phthalocyanine: A New Liquid Crystalline Discotic Material with Benzyl-Terminated, Thioether-Linked Side Chains", CHEMICAL OF MATERIALS, vol. 17.7, 2005
See also references of EP 3584245A4
RYBAK JEFFREY M. ET AL.: "Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent", PHARMACOTHERAPY, vol. 35, no. 11, 31 December 2015 (2015-12-31), pages 1037 - 1051, XP055535100, ISSN: 1875-9114
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 190447-69-9
JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 98, 2004, pages 1933 - 1946
BIOORG. MED. CHEM. LETT., vol. 15, 2005, pages 3934 - 3941
CHEM. ASIAN J, vol. 9, 2014, pages 739 - 743
MINCH, BRITT A. ET AL.: "Octakis(2-benzyloxyethylsulfanyl) Copper (II) Phthalocyanine: A New Liquid Crystalline Discotic Material with Benzyl-Terminated, Thioether-Linked Side Chains", CHEMICAL OF MATERIALS, vol. 17.7, 2005
See also references of EP 3584245A4
Attorney, Agent or Firm:
WUHAN ORIGINTELLIGENCE IP LAW FIRM (CN)
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