Title:
TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2002022602
Kind Code:
A3
Abstract:
This invention describes novel triazole compounds of formula (IX): wherein Z<1> is nitrogen or CR<9> and Z<2> is nitrogen or CH, provided that at least one of Z<1> and Z<2> is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from -R<1>; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R and R are independently selected from T-R<3>, or R and R are taken together with their intervening atoms to form a fused ring; R<1>, R<3>, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.
Inventors:
BEBBINGTON DAVID (GB)
KNEGTEL RONALD (GB)
BINCH HALEY (GB)
GOLEC JULIAN M C (GB)
LI PAN (US)
CHARRIER JEAN-DAMIEN (GB)
KNEGTEL RONALD (GB)
BINCH HALEY (GB)
GOLEC JULIAN M C (GB)
LI PAN (US)
CHARRIER JEAN-DAMIEN (GB)
Application Number:
PCT/US2001/042162
Publication Date:
June 27, 2002
Filing Date:
September 14, 2001
Export Citation:
Assignee:
VERTEX PHARMA (US)
BEBBINGTON DAVID (GB)
KNEGTEL RONALD (GB)
BINCH HALEY (GB)
GOLEC JULIAN M C (GB)
LI PAN (US)
CHARRIER JEAN-DAMIEN (GB)
BEBBINGTON DAVID (GB)
KNEGTEL RONALD (GB)
BINCH HALEY (GB)
GOLEC JULIAN M C (GB)
LI PAN (US)
CHARRIER JEAN-DAMIEN (GB)
International Classes:
A61K31/415; A61K31/437; A61K31/4709; A61K31/4725; A61K31/501; A61K31/5025; A61K31/506; A61K31/517; A61K31/519; A61K31/52; A61K31/53; A61K31/5377; C07D403/12; A61K31/541; A61K31/55; A61K45/00; A61P1/16; A61P3/08; A61P3/10; A61P3/14; A61P5/00; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P25/18; A61P25/28; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D239/26; C07D239/36; C07D239/70; C07D239/88; C07D401/12; C07D401/14; C07D403/14; C07D405/14; C07D407/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D473/16; C07D475/10; C07D487/04; C07D491/04; C07D491/044; C07D491/048; C07D491/052; C07D491/107; C07D491/113; C07D491/20; C07D493/04; C07D495/04; C07D498/04; C07D513/04; C07D521/00; (IPC1-7): A61K31/506; A61K31/519; A61P3/10; A61P25/18; A61P35/00; C07D403/12; C07D471/04; C07D401/14; C07D409/14; C07D405/14; C07D491/04; C07D403/14
Domestic Patent References:
| WO2000042029A1 | 2000-07-20 | |||
| WO1998002434A1 | 1998-01-22 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; IVASHCHENKO, A. V. ET AL: "Synthesis and study of heteroaromatic ligands containing a pyrimidine ring", XP002189864, retrieved from STN Database accession no. 94:139736
TRAXLER P ET AL: "USE OF A PHARMACOPHORE MODEL FOR THE DESIGN OF EGF-R TYROSINE KINASE INHIBITORS: 4-(PHENYLAMINO)PYRAZOLO3,4-DPYRIMIDINES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, no. 22, 1997, pages 3601 - 3616, XP001009913, ISSN: 0022-2623
TRAXLER P ET AL: "USE OF A PHARMACOPHORE MODEL FOR THE DESIGN OF EGF-R TYROSINE KINASE INHIBITORS: 4-(PHENYLAMINO)PYRAZOLO3,4-DPYRIMIDINES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, no. 22, 1997, pages 3601 - 3616, XP001009913, ISSN: 0022-2623
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