TRIAZOLE DERIVATIVE OR SALT THEREOF

WIPO Patent Application WO/2007/105753

A1

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), particularly diabetes or insulin resistance. [MEANS FOR SOLVING PROBLEMS] Disclosed is a triazole derivative which has a triazole ring substituted by a 3-substituted methyl group at position-3 and further substituted by a lower alkyl, a cycloalkyl or the like at position-5, or a pharmaceutically acceptable salt thereof. It is found that the triazole derivative or the salt thereof has a potent inhibitory activity on 11β-HSD1. The triazole derivative has an excellent anti-hyperglycemic activity and therefore can be used for the treatment of diabetes or insulin resistance.

YOSHIMURA SEIJI (JP)
SHIRAKI RYOTA (JP)
KAWANO TOMOAKI (JP)
SASUGA DAISUKE (JP)
HOSAKA MITSURU (JP)
FUKUDOME HIROKI (JP)
KUROSAWA KAZUO (JP)
ISHII HIROFUMI (JP)
KOIKE TAKANORI (JP)

PCT/JP2007/055048

September 20, 2007

March 14, 2007

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ASTELLAS PHARMA INC (JP)
YOSHIMURA SEIJI (JP)
SHIRAKI RYOTA (JP)
KAWANO TOMOAKI (JP)
SASUGA DAISUKE (JP)
HOSAKA MITSURU (JP)
FUKUDOME HIROKI (JP)
KUROSAWA KAZUO (JP)
ISHII HIROFUMI (JP)
KOIKE TAKANORI (JP)

C07D249/08; A61K31/4196; A61K31/4245; A61K31/427; A61K31/4439; A61K31/444; A61K31/4709; A61K31/497; A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P19/10; A61P25/28; A61P27/06; A61P43/00; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/08; C07D409/06; C07D409/08; C07D409/12; C07D413/06; C07D417/06

WO2005044192A2	2005-05-19
WO2006030805A1	2006-03-23
WO2006080533A1	2006-08-03
WO2003065983A2	2003-08-14
WO2003104207A2	2003-12-18
WO2003104208A1	2003-12-18
WO2004089367A1	2004-10-21
WO2004089380A2	2004-10-21
WO2005044192A2	2005-05-19
WO2006030805A1	2006-03-23

JP2005170939A	2005-06-30
US20040133011A1	2004-07-08
JP2005170939A	2005-06-30
US4577020A	1986-03-18
US3907821A	1975-09-23

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See also references of EP 1995243A4

MORITA, Hiroshi et al. (Intellectual Property, 3-11, Nihonbashi-Honcho 2-chome,, Chuo-k, Tokyo11, JP)

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