Title:
TRIAZOLOPYRIDINES AND TRIAZOLOPYRIMIDINES THAT LOWER STRESS-INDUCED P-TAU
Document Type and Number:
WIPO Patent Application WO/2016/134042
Kind Code:
A3
Abstract:
In certain embodiments compounds (e.g., triazolopyrimidine(s) and/or triazolopyridine(s)) are provided that are effective to lower p-tau and/or to prevent or reduce elevation of p-tau, particularly in response to stress (e.g., elevated cortisol levels). The 5 compounds are useful in the treatment or prophylaxis of pathologies characterized by abnormal amyloid plaque and or tangle formation and/or deposition.
Inventors:
JOHN VARGHESE (US)
BREDESEN DALE E (US)
BREDESEN DALE E (US)
Application Number:
PCT/US2016/018305
Publication Date:
October 13, 2016
Filing Date:
February 17, 2016
Export Citation:
Assignee:
BUCK INST FOR RES ON AGING (US)
International Classes:
C07D487/04; A61K31/519; A61P25/00; A61P25/28
Domestic Patent References:
| WO2014047257A2 | 2014-03-27 |
Foreign References:
| US6448261B1 | 2002-09-10 | |||
| US6107301A | 2000-08-22 | |||
| EP1293213A1 | 2003-03-19 | |||
| US20010025042A1 | 2001-09-27 |
Other References:
See also references of EP 3259274A4
Attorney, Agent or Firm:
HUNTER, Tom et al. (Oakland, California, US)
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