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Patent Searching and Data


Title:
TRIAZOLYL PYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2016/145614
Kind Code:
A1
Abstract:
The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Inventors:
SHEN DONG-MING (US)
SINZ CHRISTOPHER J (US)
CRESPO ALEXANDER (US)
WILSON JONATHAN E (US)
MCCRACKEN TROY (US)
XU SHIMIN (CN)
LI HAITANG (CN)
Application Number:
PCT/CN2015/074396
Publication Date:
September 22, 2016
Filing Date:
March 17, 2015
Export Citation:
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Assignee:
MERCK SHARP & DOHME (US)
SHEN DONG-MING (US)
SINZ CHRISTOPHER J (US)
CRESPO ALEXANDER (US)
WILSON JONATHAN E (US)
MCCRACKEN TROY (US)
XU SHIMIN (CN)
LI HAITANG (CN)
International Classes:
C07D239/36; A61K31/4192; A61K31/4196; A61K31/505; A61P25/00; A61P25/14; A61P25/16; A61P25/22; A61P25/24; C07D249/06; C07D249/08
Domestic Patent References:
WO2006072615A22006-07-13
WO1998049166A11998-11-05
Attorney, Agent or Firm:
WU, FENG & ZHANG CO. (Tower B,Beijing Aerospace Cpmiec Building,No. 30, Haidian South Road, Haidian District, Beijing 0, CN)
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