Title:
TRICARBOXYLIC ACID DERIVATIVE HAVING SQUALENE SYNTHETASE INHIBITOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO/1995/004025
Kind Code:
A1
Abstract:
A compound represented by following general formula (1): R1-A-R2, stereoisomers and optical isomers thereof, and pharmaceutically acceptable salts thereof. This compound has a potent squalene synthetase inhibitor activity and is useful as a cholesterol-lowering agent. In the formula, R1 represents optionally substituted saturated or unsaturated alkyl; R2 represents a group represented by general formula (2) (wherein R3, R4 and R5 represent each hydrogen or lower alkyl; R6 represents hydrogen or alkyl; and n represents 1 or 2) general formula (3) (wherein R3, R4 and R5 represents each hydrogen or lower alkyl; and R6 represents hydrogen or hydroxy, general formula (4) (wherein R3 represents lower alkyl), or general formula (5) (wherein R3, R4 and R5 represent each hydrogen or lower alkyl; and R6 represents hydrogen or alkyl); and A represents O, S, SO or NR7.
Inventors:
KOBAYASHI TAKAMITSU (JP)
TAMURA KUNIO (JP)
YOSHIDA MITSUTAKA (JP)
KOGA HIROSHI (JP)
TAMURA KUNIO (JP)
YOSHIDA MITSUTAKA (JP)
KOGA HIROSHI (JP)
Application Number:
PCT/JP1994/001249
Publication Date:
February 09, 1995
Filing Date:
July 29, 1994
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
KOBAYASHI TAKAMITSU (JP)
TAMURA KUNIO (JP)
YOSHIDA MITSUTAKA (JP)
KOGA HIROSHI (JP)
KOBAYASHI TAKAMITSU (JP)
TAMURA KUNIO (JP)
YOSHIDA MITSUTAKA (JP)
KOGA HIROSHI (JP)
International Classes:
C07C59/305; C07C69/708; C07C229/24; C07C317/44; C07C323/52; C07D213/38; C07D213/65; C07D317/64; (IPC1-7): C07C59/305; C07C69/708; C07C229/06; C07C229/24; C07C317/22; C07C317/44; C07C323/19; C07C323/51; C07D213/55; C07D213/65; C07D317/64
Foreign References:
| EP0448078A2 | 1991-09-25 | |||
| JPH04221327A | 1992-08-11 | |||
| JPH04217986A | 1992-08-07 | |||
| JPS62265279A | 1987-11-18 | |||
| JPH03115274A | 1991-05-16 | |||
| JPS5283676A | 1977-07-12 |
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