Title:
TRICYCLIC COMPOUND AS SELECTIVE ESTROGEN RECEPTOR DOWN-REGULATOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/130124
Kind Code:
A1
Abstract:
The present invention falls within the field of medical chemistry, and relates to a tricyclic compound as a selective estrogen receptor down-regulator and the use thereof. In particular, provided in the present invention are a compound as shown in formula I or an isomer, a pharmaceutically acceptable salt, a solvate, a crystal or a prodrug thereof, the preparation method therefor and pharmaceutical compositions containing the compounds and the use of the compounds or compositions for treating and/or preventing estrogen receptor-associated diseases. The compound of the present invention has an even better anti-tumour activity, a longer dosing interval and fewer side effects, and seems to be very promising as a therapeutic agent against breast cancer.
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Inventors:
WANG YONG (CN)
ZHAO LIWEN (CN)
WANG XIAOWEI (CN)
ZHANG XIAOMENG (CN)
ZHANG YAN (CN)
PANG SILIN (CN)
ZHAO LIWEN (CN)
WANG XIAOWEI (CN)
ZHANG XIAOMENG (CN)
ZHANG YAN (CN)
PANG SILIN (CN)
Application Number:
PCT/CN2018/071700
Publication Date:
July 19, 2018
Filing Date:
January 08, 2018
Export Citation:
Assignee:
NANJING SANHOME PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/437; C07D471/04; A61K31/4545; A61P25/06; A61P25/28; A61P25/32; A61P35/00
Domestic Patent References:
| WO2010138652A1 | 2010-12-02 | |||
| WO2010138706A1 | 2010-12-02 | |||
| WO2016097071A1 | 2016-06-23 |
Foreign References:
| CN105229004A | 2016-01-06 |
Attorney, Agent or Firm:
NANJING ZHONGLIAN PATENT AGENCY CO., LTD (CN)
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