Title:
TRICYCLIC COMPOUND HAVING ANTIALLERGIC EFFECT
Document Type and Number:
WIPO Patent Application WO/1993/022313
Kind Code:
A1
Abstract:
A nitrogenous tricyclic compound represented by general formula (I), a salt and a solvate thereof, and a solvate of a salt thereof, each inhibiting the production of an IgE antibody and being useful as a prophylactic and/or a therapeutic agent for allergic diseases, wherein R represents halogen, linear or branched C1-C10 alkyl which may be substituted by one or more halogen atoms, or phenyl or napthyl each of which may be substituted by 1 to 5 specified groups; Y represents hydrogen and Z represents hydrogen, hydroxy or a specified group, or alternatively Y and Z may be combined together to represent hydrazono or hydroximino each of which may be substituted by a specified group, or a specified group; and X1-X2 ~ C ~ X3 represents CH-N-C=C or N-C=C-N, provided that when it is N-C=C-N, then Y and Z are neither hydroximino nor oxygen.
Inventors:
MOCHIZUKI HIDENORI (JP)
KATO KAZUO (JP)
YAMAMOTO ICHIRO (JP)
MIZUGUCHI KIYOSHI (JP)
KATO KAZUO (JP)
YAMAMOTO ICHIRO (JP)
MIZUGUCHI KIYOSHI (JP)
Application Number:
PCT/JP1993/000549
Publication Date:
November 11, 1993
Filing Date:
April 27, 1993
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
MOCHIZUKI HIDENORI (JP)
KATO KAZUO (JP)
YAMAMOTO ICHIRO (JP)
MIZUGUCHI KIYOSHI (JP)
MOCHIZUKI HIDENORI (JP)
KATO KAZUO (JP)
YAMAMOTO ICHIRO (JP)
MIZUGUCHI KIYOSHI (JP)
International Classes:
C07D471/06; (IPC1-7): C07D471/06; A61K31/435; A61K31/47
Foreign References:
| JPH04145083A | 1992-05-19 | |||
| JPH0327382A | 1991-02-05 |
Other References:
Heterocycles, Vol. 31, No. 3, (1990), M. NOGUCHI et al., "Studies on Nitrogen-Bridged Heterocycles. VII. Synthesis and Properties of 6H-benzo(h, i)pyrrolo(2,1,5-c,d)indolizine-6-ones", p. 563-568.
Bull. Chem. Soc. Jpn., Vol. 61, No. 2, (1988), M. NOGUCHI et al., "Studies on Nitrogen-Bridged Heterocycles. VI. Synthesis and Properties of 4H-benzo(h, i)pyrrolo(2,1,5-c,d)indolizine-4-ones", p. 423-429.
J. Org. Chem., Vol. 47, No. 4, (1982), M. CARDELLINI et al., "Indolizine Derivatives Related to Ergoline", p. 688-692.
Eur. J. Med. Chem. - Chim. Ther., Vol. 12, No. 5, (1977), "Study of Activity in the Imidazo(4,5,1-i,j)quinoline Series", p. 471-476.
Steroides, Vol. 27, No. 2, (1976), "Total Synthesis of Diazasteroides", p. 205-210.
See also references of EP 0638570A4
Bull. Chem. Soc. Jpn., Vol. 61, No. 2, (1988), M. NOGUCHI et al., "Studies on Nitrogen-Bridged Heterocycles. VI. Synthesis and Properties of 4H-benzo(h, i)pyrrolo(2,1,5-c,d)indolizine-4-ones", p. 423-429.
J. Org. Chem., Vol. 47, No. 4, (1982), M. CARDELLINI et al., "Indolizine Derivatives Related to Ergoline", p. 688-692.
Eur. J. Med. Chem. - Chim. Ther., Vol. 12, No. 5, (1977), "Study of Activity in the Imidazo(4,5,1-i,j)quinoline Series", p. 471-476.
Steroides, Vol. 27, No. 2, (1976), "Total Synthesis of Diazasteroides", p. 205-210.
See also references of EP 0638570A4
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