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Title:
TRICYCLIC COMPOUND AND JAK INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2015/174376
Kind Code:
A1
Abstract:
Provided is a novel tricyclic compound which has JAK inhibitory activity and is especially useful for prophylaxis, treatment or amelioration of autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic compound which is represented by formula (I), formula (II) or formula (III) (wherein each of A1, A2 and A3 represents a cyclohexane-1,4-diyl group or the like; each of L1, L2 and L3 represents a methylene group or the like; each of X1 and X3 represents O or NH; each of R1 and R3 represents a cyano C1-6 haloalkyl group or the like; and R2 represents an aromatic heterocyclic group), a tautomer or a pharmaceutically acceptable salt of the compound, or a solvate of the compound, the tautomer or the pharmaceutically acceptable salt.

Inventors:
WATANABE TSUNEO (JP)
TAKAHASHI KEIJI (JP)
HAYASHI KEISHI (JP)
NAKAMURA TAKANORI (JP)
MINAMI MASATAKA (JP)
KURIHARA KAZUNORI (JP)
YAMAMOTO AKIO (JP)
NISHIMURA TAKUYA (JP)
UNI MIYUKI (JP)
KAMIYAMA TOSHIHIKO (JP)
IWAMOTO SHUNSUKE (JP)
Application Number:
JP2015/063504
Publication Date:
November 19, 2015
Filing Date:
May 11, 2015
Export Citation:
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Assignee:
NISSAN CHEMICAL IND LTD (JP)
International Classes:
C07D471/14; A61K31/4375; A61K31/519; A61P29/00; A61P43/00
Domestic Patent References:
WO2013024895A12013-02-21
WO2014123167A12014-08-14
WO2012085176A12012-06-28
Foreign References:
JP2013517220A2013-05-16
JP2013512282A2013-04-11
Other References:
See also references of EP 3144309A4
Attorney, Agent or Firm:
SENMYO, Kenji et al. (JP)
Spring name Kenji (JP)
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