Title:
TRICYCLIC COMPOUND USED AS GPR84 ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2022/268088
Kind Code:
A1
Abstract:
The present invention relates to a tricyclic compound used as a GPR84 antagonist, and in particular relates to a tricyclic compound having a structure shown in formula I, and tautomers, stereoisomers, hydrates, solvates, pharmaceutically acceptable salts or prodrugs thereof; the definitions of the ring Cy, L1, R1 are as described in the present invention; the tricyclic compound has significant GPR84 antagonism, good pharmaceutical developability and high safety.
Inventors:
ZHANG XUEJUN (CN)
ZANG YANG (CN)
WEI WENJUN (CN)
LI QUN (CN)
ZHAO XIN (CN)
XU QING (CN)
NI PING (CN)
LI LI'E (CN)
YANG JUN (CN)
ZANG YANG (CN)
WEI WENJUN (CN)
LI QUN (CN)
ZHAO XIN (CN)
XU QING (CN)
NI PING (CN)
LI LI'E (CN)
YANG JUN (CN)
Application Number:
PCT/CN2022/100224
Publication Date:
December 29, 2022
Filing Date:
June 21, 2022
Export Citation:
Assignee:
WUHAN HUMANWELL INNOVATIVE DRUG RES AND DEVELOPMENT CENTER LIMITED COMPANY (CN)
International Classes:
C07D471/04; A61K31/4375; A61P29/00; C07D519/00
Domestic Patent References:
| WO2015197550A1 | 2015-12-30 | |||
| WO2013092791A1 | 2013-06-27 |
Foreign References:
| CN104870445A | 2015-08-26 | |||
| CN111343986A | 2020-06-26 | |||
| CN103998448A | 2014-08-20 | |||
| CN202110685568A | 2021-06-21 |
Other References:
LABÉGUÈRE FRÉDÉRIC, DUPONT SONIA, ALVEY LUKE, SOULAS FLORILÈNE, NEWSOME GREGORY, TIRERA AMYNATA, QUENEHEN VANESSA, MAI THI THU TRA: "Discovery of 9-Cyclopropylethynyl-2-(( S )-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1- a ]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 22, 25 November 2020 (2020-11-25), US , pages 13526 - 13545, XP055914991, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00272
MAEHR, J. CHEM. ED., vol. 62, 1985, pages 114 - 120
MAEHR, J. CHEM. ED., vol. 62, 1985, pages 114 - 120
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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