Title:
TRICYCLIC COMPOUNDS HAVING sPLA¿2?-INHIBITORY ACTIVITIES
Document Type and Number:
WIPO Patent Application WO/2001/009130
Kind Code:
A1
Abstract:
Compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or hydrates of them, exhibiting sPLA¿2-inhibitory activities: In formula (I) R?1¿ is C¿1?-C¿20? alkyl, C¿2?-C¿20? alkenyl, C¿2?-C¿20? alkynyl, a carbocyclic group, a heterocyclic group, or the like; R?2¿ is CONH¿2? or CONHNH¿2?; and either of R?3¿ and either of R?3¿ and R?4¿ is -(L?2¿)-(acid group) (wherein L?2¿ is a group connecting with an acid group and the length of the connecting group is 1 to 5) and the other is hydrogen.
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Inventors:
OHTANI MITSUAKI (JP)
FUJI MASAHIRO (JP)
OKADA TETSUO (JP)
ADACHI MAKOTO (JP)
OGAWA TOMOYUKI (JP)
FUJI MASAHIRO (JP)
OKADA TETSUO (JP)
ADACHI MAKOTO (JP)
OGAWA TOMOYUKI (JP)
Application Number:
PCT/JP2000/004908
Publication Date:
February 08, 2001
Filing Date:
July 24, 2000
Export Citation:
Assignee:
SHIONOGI & CO (JP)
OHTANI MITSUAKI (JP)
FUJI MASAHIRO (JP)
OKADA TETSUO (JP)
ADACHI MAKOTO (JP)
OGAWA TOMOYUKI (JP)
OHTANI MITSUAKI (JP)
FUJI MASAHIRO (JP)
OKADA TETSUO (JP)
ADACHI MAKOTO (JP)
OGAWA TOMOYUKI (JP)
International Classes:
A61P29/00; C07D471/04; C07D471/14; C07D491/14; C07D491/147; C07D498/14; (IPC1-7): C07D471/04; A61K31/437; A61K31/5025; A61P29/00; C07D471/14; C07D491/147; C07D498/14
Domestic Patent References:
| WO1996003383A1 | 1996-02-08 |
Other References:
MATSUMOTO KIYOSHI ET AL.: "1,3-Dipolar cycloaddition reactions of cyclooctyne with pyridinium dicyanomethylides", J. HETEROCYCL. CHEM., vol. 34, no. 1, 1997, pages 203 - 208, XP002932591
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Intellectual Property Department 12-4
Sagisu 5-chom, Fukushima-ku Osaka-shi Osaka, JP)
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