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Title:
TRICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO/1987/005014
Kind Code:
A1
Abstract:
Compounds represented by general formula (I), (wherein Y-Z represents (II), -CH=CH- or -CH2CH2-, R1 and R2 each represents a substituent, R3 represents hydrogen, alkyl or alkoxy, R4 represents hydrogen, alkyl, optionally substituted alkenyl, alkynyl, optionally substituted cycloalkyl, phenyl, monocyclic heteroaryl or substituted alkyl, R5 represents phenyl, substituted phenyl or monocyclic heteroaryl, W represents alkylene, X represents a single bond, optionally substituted alkylene, or alkylene interrupted by a group selected from among -O-, -S-, (III) and -CH=CH- or bound to R5 through one of these groups, and a represents an integer of 0 to 2), salts thereof, a process for their preparation, and a medicinal composition containing them. The compounds and the salts show such a strong calcium-antagonistic effect that they are useful for prophylaxis and/or treatment of hypertensive and/or ischemic heart diseases.

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Inventors:
Uno
Hitoshi, Kurokawa
Mikio, Sato
Fuminori, Naruto
Shunsuke, Hosoki
Kanoo, Takeyama
Kunihiko
Application Number:
PCT/JP1987/000085
Publication Date:
August 27, 1987
Filing Date:
February 10, 1987
Export Citation:
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Assignee:
Dainippon
Pharmaceutical
CO., LTD.
Uno, Hitoshi
Kurokawa, Mikio
Sato, Fuminori
Naruto, Shunsuke
Hosoki, Kanoo
Takeyama, Kunihiko
International Classes:
C07D335/18; A61K31/135; A61K31/165; A61K31/195; A61K31/275; A61K31/33; A61K31/435; A61P3/00; A61P3/14; A61P9/08; A61P9/10; A61P9/12; C07C67/00; C07C231/00; C07C237/04; C07C237/06; C07C237/12; C07C237/22; C07C239/00; C07C241/00; C07C243/22; C07C243/24; C07C253/00; C07C255/47; C07C255/55; C07C255/58; C07C255/60; C07C273/10; C07C275/04; C07C311/00; C07C313/00; C07C323/25; C07C323/30; C07C323/32; C07C323/36; C07C323/38; C07C325/00; C07C327/20; C07D213/38; C07D219/10; C07D307/14; C07D307/52; C07D309/04; C07D309/14; C07D311/88; C07D313/12; C07D333/20; C07D333/76; C07D337/12; C07D409/12; C07D409/14; C07D413/12; (IPC1-7): C07C83/10; C07C103/50; C07C149/24; C07D213/36; C07D333/20; C07D337/12; C07D405/12; C07D409/12; A61K31/645
Other References:
"Journal of Pharmaceutical Sciences", Vol. 72, No. 10, P. 1172, Table V.
"Journal of Medicinal Chemistry", Vol. 32, No. 2, p. 184-187.
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