Title:
TRICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO/1987/005014
Kind Code:
A1
Abstract:
Compounds represented by general formula (I), (wherein Y-Z represents (II), -CH=CH- or -CH2CH2-, R1 and R2 each represents a substituent, R3 represents hydrogen, alkyl or alkoxy, R4 represents hydrogen, alkyl, optionally substituted alkenyl, alkynyl, optionally substituted cycloalkyl, phenyl, monocyclic heteroaryl or substituted alkyl, R5 represents phenyl, substituted phenyl or monocyclic heteroaryl, W represents alkylene, X represents a single bond, optionally substituted alkylene, or alkylene interrupted by a group selected from among -O-, -S-, (III) and -CH=CH- or bound to R5 through one of these groups, and a represents an integer of 0 to 2), salts thereof, a process for their preparation, and a medicinal composition containing them. The compounds and the salts show such a strong calcium-antagonistic effect that they are useful for prophylaxis and/or treatment of hypertensive and/or ischemic heart diseases.
More Like This:
| JP61047466 | AMINE DERIVATIVE |
| WO/1993/021176 | NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF |
| JP62153280 | 1,4-DIAZACYCLOALKANE DERIVATIVE |
Inventors:
Uno
Hitoshi, Kurokawa
Mikio, Sato
Fuminori, Naruto
Shunsuke, Hosoki
Kanoo, Takeyama
Kunihiko
Hitoshi, Kurokawa
Mikio, Sato
Fuminori, Naruto
Shunsuke, Hosoki
Kanoo, Takeyama
Kunihiko
Application Number:
PCT/JP1987/000085
Publication Date:
August 27, 1987
Filing Date:
February 10, 1987
Export Citation:
Assignee:
Dainippon
Pharmaceutical
CO., LTD.
Uno, Hitoshi
Kurokawa, Mikio
Sato, Fuminori
Naruto, Shunsuke
Hosoki, Kanoo
Takeyama, Kunihiko
Pharmaceutical
CO., LTD.
Uno, Hitoshi
Kurokawa, Mikio
Sato, Fuminori
Naruto, Shunsuke
Hosoki, Kanoo
Takeyama, Kunihiko
International Classes:
C07D335/18; A61K31/135; A61K31/165; A61K31/195; A61K31/275; A61K31/33; A61K31/435; A61P3/00; A61P3/14; A61P9/08; A61P9/10; A61P9/12; C07C67/00; C07C231/00; C07C237/04; C07C237/06; C07C237/12; C07C237/22; C07C239/00; C07C241/00; C07C243/22; C07C243/24; C07C253/00; C07C255/47; C07C255/55; C07C255/58; C07C255/60; C07C273/10; C07C275/04; C07C311/00; C07C313/00; C07C323/25; C07C323/30; C07C323/32; C07C323/36; C07C323/38; C07C325/00; C07C327/20; C07D213/38; C07D219/10; C07D307/14; C07D307/52; C07D309/04; C07D309/14; C07D311/88; C07D313/12; C07D333/20; C07D333/76; C07D337/12; C07D409/12; C07D409/14; C07D413/12; (IPC1-7): C07C83/10; C07C103/50; C07C149/24; C07D213/36; C07D333/20; C07D337/12; C07D405/12; C07D409/12; A61K31/645
Download PDF: