Title:
TRICYCLIC COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/175223
Kind Code:
A1
Abstract:
Provided are the following: compounds having a powerful anti-bacterial spectrum against a variety of bacteria, including gram-negative bacteria and gram-positive bacteria; and pharmaceutical compositions having antibacterial activity against carbapenem-resistant bacteria.
Provided are the following: a compound represented by formula (I): (in the formula, -Z- is a single bond or -CR7AR7B-, R7A and R7B are each independently a hydrogen atom or the like, Y is N or CH, -W- is -S-, -S-CH2-, -CH2-S- or -CH2-, -T- is -CR4AR4B- or -CR5AR5B-CR6AR6B-, R4A, R4B, R5A, R5B, R6A and R6B are each independently a hydrogen atom or the like, R16 is a carboxyl group, a tetrazolyl group, or the like, R17 is a hydrogen atom or the like, R1 is a substituted or unsubstituted heterocyclic group or the like, R2A and R2B are each independently a hydrogen atom or the like or R2A and R2B bond together to form a substituted or unsubstituted methylidene group or the like, and R3 is a hydrogen atom or the like); esters of this compound; and pharmaceutically acceptable salts and hydrates thereof.
Inventors:
YAMAWAKI KENJI (JP)
KUSANO HIROKI (JP)
AOKI TOSHIAKI (JP)
KUSANO HIROKI (JP)
AOKI TOSHIAKI (JP)
Application Number:
PCT/JP2016/063138
Publication Date:
November 03, 2016
Filing Date:
April 27, 2016
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D491/147; A61K31/427; A61K31/431; A61K31/542; A61K31/546; A61P31/04; C07D499/897; C07D501/14; C07D507/00
Domestic Patent References:
| WO2008016007A1 | 2008-02-07 | |||
| WO2014198849A1 | 2014-12-18 | |||
| WO2014179885A1 | 2014-11-13 |
Foreign References:
| JPS63152384A | 1988-06-24 | |||
| JPS63107956A | 1988-05-12 | |||
| JPH01226887A | 1989-09-11 |
Other References:
YAMASHITA, Y. ET AL.: "NO cations as highly efficient catalysts for carbon-carbon bond forming reactions", CHEMISTRY LETTERS, vol. 38, no. 7, 2009, pages 678 - 679, XP055326422
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
Hideaki Yamauchi (JP)
Hideaki Yamauchi (JP)
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