TRICYCLIC COMPOUNDS - KYOWA HAKKO KOGYO KK

Title:

TRICYCLIC COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/1998/046587

Kind Code:

A1

Abstract:

Tricyclic compounds of general formula (I) and pharmacologically acceptable salts thereof, which are useful for the treatment of pollakiuria and enuresis, wherein R?1� is hydrogen, substituted or unsubstituted lower alkyl or the like; X?1�-X?2�-X?3� is CR?5�= CR?6�-CR?7�=CR?8� (wherein R?5�, R?6�, R?7� and R?8� are each independently hydrogen, substituted or unsubstituted lower alkyl, hydroxyl, substituted or unsubstituted lower alkoxy or the like), N(O)�m?=CR?5�-CR?6�-CR?7� (wherein R?5�, R?6� and R?7� are each the same as defined above; and m is 0 to 1), S-CR?7�=CR?8� (wherein R?7� and R?8� are each the same as defined above) or the like; R?2� is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, a substituted or unsubstituted N-substituted heterocyclic group or a group of general formula (a); (wherein n is 0 or 1; R?3� and R?4� are each independently hydrogen, substituted or unsubstituted lower alkyl, trifluoromethyl or the like, or alternatively R?3� and R?4� may be united to form cyclic alkyl; and Q is hydroxyl, halogeno or the like); and Y is -CH�2?SO�2?-, -SCH�2?-, -SOCH�2?-, -SO�2?CH�2?- or the like.

Inventors:

YOSHIDA MAKOTO (JP)
SEISHI TAKASHI (JP)
AONO SHIGERU (JP)
TAKAI HARUKI (JP)
SUZUKI KOJI (JP)
YAMAGATA TSUYOSHI (JP)
ATSUKI KAORU (JP)
KARASAWA AKIRA (JP)
KUMAZAWA TOSHIAKI (JP)

Application Number:

PCT/JP1998/001713

Publication Date:

October 22, 1998

Filing Date:

April 15, 1998

Export Citation:

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Assignee:

KYOWA HAKKO KOGYO KK (JP)
YOSHIDA MAKOTO (JP)
SEISHI TAKASHI (JP)
AONO SHIGERU (JP)
TAKAI HARUKI (JP)
SUZUKI KOJI (JP)
YAMAGATA TSUYOSHI (JP)
ATSUKI KAORU (JP)
KARASAWA AKIRA (JP)
KUMAZAWA TOSHIAKI (JP)

International Classes:

C07D313/12; C07D337/12; C07D495/04; (IPC1-7): C07D313/12; C07D333/06; C07D333/12; C07D495/04; A61K31/335; A61K31/38; A61K31/435

Domestic Patent References:

WO1997014672A1

1997-04-24

Foreign References:

JPH05286915A	1993-11-02
JPS61172871A	1986-08-04

Other References: