Title:
TRICYCLIC HETEROCYCLIC DERIVATIVES, COMPOSITIONS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/205914
Kind Code:
A1
Abstract:
The disclosure relates to tricyclic heterocyclic derivatives as shown in Formula (I), to pharmaceutical compositions comprising them, to a process for their preparation, and their use as therapeutic agents.
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Inventors:
YU ZHANGQI (CN)
YAN DAN (CN)
YAN DAN (CN)
Application Number:
PCT/CN2022/000075
Publication Date:
November 02, 2023
Filing Date:
April 28, 2022
Export Citation:
Assignee:
DANATLAS PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D417/14; A61K31/713; A61P35/00
Domestic Patent References:
| WO2016097749A1 | 2016-06-23 |
Other References:
CHEN SHIH-HSUN, YU XIAOCHUN: "Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies", SCIENCE ADVANCES, vol. 5, no. 4, 5 April 2019 (2019-04-05), pages eaav4340 , XP093104770, DOI: 10.1126/sciadv.aav4340
PILLAY NISHA; TIGHE ANTHONY; NELSON LOUISA; LITTLER SAMANTHA; COULSON-GILMER CAMILLA; BAH NOURDINE; GOLDER ANYA; BAKKER BJORN; SPI: "DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors", CANCER CELL, CELL PRESS, US, vol. 35, no. 3, 1 January 1900 (1900-01-01), US , pages 519, XP085638451, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2019.02.004
DOMINIC I. JAMES, KATE M. SMITH, ALLAN M. JORDAN, EMMA E. FAIRWEATHER, LOUISE A. GRIFFITHS, NICOLA S. HAMILTON, JAMES R. HITCHIN, : "First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib", ACS CHEMICAL BIOLOGY, vol. 11, no. 11, 18 November 2016 (2016-11-18), pages 3179 - 3190, XP055496287, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00609
PILLAY NISHA; TIGHE ANTHONY; NELSON LOUISA; LITTLER SAMANTHA; COULSON-GILMER CAMILLA; BAH NOURDINE; GOLDER ANYA; BAKKER BJORN; SPI: "DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors", CANCER CELL, CELL PRESS, US, vol. 35, no. 3, 1 January 1900 (1900-01-01), US , pages 519, XP085638451, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2019.02.004
DOMINIC I. JAMES, KATE M. SMITH, ALLAN M. JORDAN, EMMA E. FAIRWEATHER, LOUISE A. GRIFFITHS, NICOLA S. HAMILTON, JAMES R. HITCHIN, : "First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib", ACS CHEMICAL BIOLOGY, vol. 11, no. 11, 18 November 2016 (2016-11-18), pages 3179 - 3190, XP055496287, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00609
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