Title:
TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES
Document Type and Number:
WIPO Patent Application WO2001016136
Kind Code:
A3
Abstract:
Compounds of the formula (I) are poly(ADP-ribosyl)transferase inhibitors. Such compounds are useful as therapeutics in treating cancers and in ameliorating the effects of stroke, head trauma, and neurodegenerative disease.
Inventors:
WEBBER STEPHEN EVAN
SKALITZKY DONALD JAMES
TIKHE JAYASHREE GIRISH
KUMPF ROBERT ARNOLD
MARAKOVITS JOSEPH TIMOTHY
EASTMAN WALTER BRIAN
SKALITZKY DONALD JAMES
TIKHE JAYASHREE GIRISH
KUMPF ROBERT ARNOLD
MARAKOVITS JOSEPH TIMOTHY
EASTMAN WALTER BRIAN
Application Number:
PCT/US2000/023882
Publication Date:
June 21, 2001
Filing Date:
August 31, 2000
Export Citation:
Assignee:
AGOURON PHARMA (US)
CANCER RES CAMPAIGN TECH (GB)
CANCER RES CAMPAIGN TECH (GB)
International Classes:
A61K31/5517; A61P3/10; A61P5/50; A61P9/00; A61P9/10; A61P17/00; A61P25/00; A61P29/00; A61P35/00; C07D487/04; A61P43/00; C07D487/06; (IPC1-7): C07D487/06; A61K31/5517; A61P35/00
Domestic Patent References:
| WO1997004771A1 | 1997-02-13 |
Foreign References:
| US3734919A | 1973-05-22 |
Other References:
KUKLA, MICHAEL J. ET AL: "Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5- methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 2", J. MED. CHEM. (1991), 34(11), 3187-97, XP002162225
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GENESTE, P. ET AL: "Studies on the imidazo[4,5,1-jk][1,4]benzodiazepine and imidazo[1,5,4-ef][1,5]benzodiazepine series", XP002162228, retrieved from STN Database accession no. 88:182987
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HAERTER, H. P. ET AL: "Schmidt reaction of tetrahydroquinolone derivatives", XP002162229, retrieved from STN Database accession no. 85:32967
GATTA, FRANCO ET AL: "Derivatives of 1-phenyl-2-methyl-4,5-dihydro-6H-pyrrolo [3,2,1-ij]-6-quinolinone. I", CHIM. THER. (1973), 8(4), 455-8, XP002162226
BRESLIN, HENRY J. ET AL: "Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5- methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) Derivatives. 3", J. MED. CHEM. (1995), 38(5), 771-93, XP002162227
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GENESTE, P. ET AL: "Studies on the imidazo[4,5,1-jk][1,4]benzodiazepine and imidazo[1,5,4-ef][1,5]benzodiazepine series", XP002162228, retrieved from STN Database accession no. 88:182987
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HAERTER, H. P. ET AL: "Schmidt reaction of tetrahydroquinolone derivatives", XP002162229, retrieved from STN Database accession no. 85:32967
GATTA, FRANCO ET AL: "Derivatives of 1-phenyl-2-methyl-4,5-dihydro-6H-pyrrolo [3,2,1-ij]-6-quinolinone. I", CHIM. THER. (1973), 8(4), 455-8, XP002162226
BRESLIN, HENRY J. ET AL: "Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5- methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) Derivatives. 3", J. MED. CHEM. (1995), 38(5), 771-93, XP002162227
Download PDF: