Title:
TRICYCLIC SPIRO COMPOUND
Document Type and Number:
WIPO Patent Application WO/2016/111347
Kind Code:
A1
Abstract:
Provided is a drug the active ingredient of which is a compound having antagonistic activity against EP4 receptor in the prevention and/or treatment of disease attributed to activation of EP4 receptor. The compound represented by general formula (I) (where all symbols in the formula are the same as the symbols defined in the specification) and a salt, N-oxide, and solvate of such compound, as well as prodrugs of the foregoing, are useful as a drug ingredient having antagonistic activity against EP4 receptor in the prevention and/or treatment of disease attributed to activation of EP4 receptor.
Inventors:
ASADA MASAKI (JP)
TANI KOUSUKE (JP)
HIROBE MASAYA (JP)
HIGUCHI SATONORI (JP)
FUCHIBE KAZUHIRO (JP)
OIKAWA RYO (JP)
KOTANI TOHRU (JP)
TAKANO HIROTSUGU (JP)
TANI KOUSUKE (JP)
HIROBE MASAYA (JP)
HIGUCHI SATONORI (JP)
FUCHIBE KAZUHIRO (JP)
OIKAWA RYO (JP)
KOTANI TOHRU (JP)
TAKANO HIROTSUGU (JP)
Application Number:
PCT/JP2016/050446
Publication Date:
July 14, 2016
Filing Date:
January 08, 2016
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07C255/63; A61K31/277; A61K31/343; A61K31/352; A61K31/381; A61K31/397; A61K31/4025; A61K31/415; A61K31/4155; A61K31/4192; A61K31/422; A61K31/4245; A61K31/427; A61K31/437; A61K31/4406; A61K31/4433; A61K31/4439; A61K31/453; A61K31/497; A61K31/501; A61K31/506; A61K31/5383; A61K33/243; A61K39/395; A61K45/00; A61P1/02; A61P1/04; A61P1/16; A61P9/00; A61P19/00; A61P21/00; A61P25/04; A61P35/00; A61P37/06; A61P43/00; C07D213/56; C07D231/12; C07D307/94; C07D311/96; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D413/12; C07D417/12; C07D471/04; C07D498/04
Domestic Patent References:
| WO2003016254A1 | 2003-02-27 | |||
| WO2002016311A1 | 2002-02-28 | |||
| WO2004037247A1 | 2004-05-06 |
Foreign References:
| JP2002526517A | 2002-08-20 | |||
| JP2002506851A | 2002-03-05 | |||
| JP2004517099A | 2004-06-10 | |||
| JPH05222049A | 1993-08-31 |
Other References:
DATABASE REGISTRY 18 March 2014 (2014-03-18), retrieved from STN Database accession no. 1569670
See also references of EP 3243813A4
See also references of EP 3243813A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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