Title:
TRICYCLIC AND TETRACYCLIC SYSTEMS WITH ACTIVITY ON THE CENTRAL-NERVOUS AND VASCULAR SYSTEMS
Document Type and Number:
WIPO Patent Application WO/2011/041989
Kind Code:
A3
Abstract:
The present invention relates to chemistry and pharmacy and, in particular, to the production of novel molecular entities, tricyclic and tetracyclic derivatives of benzodiazepine, pyridodiazepine and pyrimidodiazepine type fused with 1,4-dihydropyridine derivatives, having an effect on the central-nervous and vascular systems. Derivatives containing a dihydropyridine ring are used, by means of reactions with compounds of the ortho-phenylenediamine, ortho-diaminopyridine and ortho-diaminopyrimidine type, and also subsequent conversions to some thereof, to obtain tricyclic and tetracyclic derivatives of general formula I-XII that contain a diazepine or diazepinone nucleus fused to a 1,4- dihydropyridine nucleus, in which the A ring is a substituted or unsubstituted benzene, pyridine or pyrimidine ring. Said molecular entities exhibit GABAergica and modulating action in the case of calcium channels which can be used in the treatment of cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric and neurological disorders.
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Inventors:
VERDECIA REYES YAMILA (CU)
OCHOA RODRIGUEZ ESTAEL (CU)
RUIZ REYES ALBERTO (CU)
NUNEZ FIGUEREDO YANIER (CU)
CARILLO DOMINGUEZ CARMEN (CU)
TACORONTE MORALES JUAN ENRIQUE (CU)
ALBA GUTIERREZ LIVAN LAZARO (CU)
PARDO ANDREU GILBERTO LAZARO (CU)
OCHOA RODRIGUEZ ESTAEL (CU)
RUIZ REYES ALBERTO (CU)
NUNEZ FIGUEREDO YANIER (CU)
CARILLO DOMINGUEZ CARMEN (CU)
TACORONTE MORALES JUAN ENRIQUE (CU)
ALBA GUTIERREZ LIVAN LAZARO (CU)
PARDO ANDREU GILBERTO LAZARO (CU)
Application Number:
PCT/CU2010/000004
Publication Date:
September 15, 2011
Filing Date:
October 08, 2010
Export Citation:
Assignee:
CT DE INVESTIGACION Y DESARROLLO DE MEDICAMENTOS CIDEM (CU)
SINTESIS ORGANICA DE LA FACULTAD DE QUIMICA DE LA UNIVERSIDAD DE LA HABANA LAB DE (CU)
VERDECIA REYES YAMILA (CU)
OCHOA RODRIGUEZ ESTAEL (CU)
RUIZ REYES ALBERTO (CU)
NUNEZ FIGUEREDO YANIER (CU)
CARILLO DOMINGUEZ CARMEN (CU)
TACORONTE MORALES JUAN ENRIQUE (CU)
ALBA GUTIERREZ LIVAN LAZARO (CU)
PARDO ANDREU GILBERTO LAZARO (CU)
SINTESIS ORGANICA DE LA FACULTAD DE QUIMICA DE LA UNIVERSIDAD DE LA HABANA LAB DE (CU)
VERDECIA REYES YAMILA (CU)
OCHOA RODRIGUEZ ESTAEL (CU)
RUIZ REYES ALBERTO (CU)
NUNEZ FIGUEREDO YANIER (CU)
CARILLO DOMINGUEZ CARMEN (CU)
TACORONTE MORALES JUAN ENRIQUE (CU)
ALBA GUTIERREZ LIVAN LAZARO (CU)
PARDO ANDREU GILBERTO LAZARO (CU)
International Classes:
C07D471/04; A61K31/551; A61K31/5513; A61P9/00; A61P25/00; A61P25/28; C07D471/14; C07D471/22; C07D491/147; C07D491/22
Foreign References:
| EP0498290A1 | 1992-08-12 | |||
| US5571809A | 1996-11-05 | |||
| US3780047A | 1973-12-18 | |||
| US4012373A | 1977-03-15 |
Other References:
FAILLI, A.A. ET AL.: "Pyridobenzodiazepines: A novel class of orally active, vasopressin V2 receptor selective agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 954 - 959, XP008156247
OKAMOTO, Y. ET AL.: "A Novel Synthesis of Pyrido[2,3b][1,5]benzodiazepines", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, 1994, pages 49 - 52, XP008156248
RAMA RAO, K. ET AL.: "Synthesis of Novel Quino[2,3-b][1,5]benzodiazepin-12-ones", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 28, 1991, pages 1339 - 1340, XP008156250
See also references of EP 2487174A4
OKAMOTO, Y. ET AL.: "A Novel Synthesis of Pyrido[2,3b][1,5]benzodiazepines", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, 1994, pages 49 - 52, XP008156248
RAMA RAO, K. ET AL.: "Synthesis of Novel Quino[2,3-b][1,5]benzodiazepin-12-ones", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 28, 1991, pages 1339 - 1340, XP008156250
See also references of EP 2487174A4
Attorney, Agent or Firm:
VÁSQUEZ D'ALVARÉ, Dánice (Miramar. Playa, CEP : Ciudad de la Habana, CU)
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