TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND ANTIALLERGIC

Title:

TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND ANTIALLERGIC

Document Type and Number:

WIPO Patent Application WO/1999/016770

Kind Code:

A1

Abstract:

Tricyclic triazolobenzazepine derivatives in the form of a prodrug. The compounds are ones represented by general formula (I) and pharmacologically acceptable salts and solvates thereof. They are useful as an antiallergic and have excellent bioavailability. In formula (I), R?1¿ represents hydrogen, OH, alkyl, or phenylalkyl; R?2¿, R?3¿, R?4¿, and R?5¿ each represents hydrogen, halogeno, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy, etc.; and Q represents a group selected among groups (i) to (iv), halogeno, or alkoxy.

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Inventors:

OHTSUKA YASUO (JP)
NISHIZUKA TOSHIO (JP)
SHIOKAWA SOHJIRO (JP)
TSUTSUMI SEIJI (JP)
KAWAGUCHI MAMI (JP)
KITAGAWA HIDEO (JP)
TAKATA HIROMI (JP)
SHISHIKURA TAKASHI (JP)
ISHIKURA TOYOAKI (JP)
FUSHIHARA KENICHI (JP)
OKADA YUMIKO (JP)
MIYAMOTO SACHIKO (JP)
SHIOBARA MAKI (JP)

Application Number:

PCT/JP1998/004363

Publication Date:

April 08, 1999

Filing Date:

September 29, 1998

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Assignee:

MEIJI SEIKA KAISHA (JP)
OHTSUKA YASUO (JP)
NISHIZUKA TOSHIO (JP)
SHIOKAWA SOHJIRO (JP)
TSUTSUMI SEIJI (JP)
KAWAGUCHI MAMI (JP)
KITAGAWA HIDEO (JP)
TAKATA HIROMI (JP)
SHISHIKURA TAKASHI (JP)
ISHIKURA TOYOAKI (JP)
FUSHIHARA KENICHI (JP)
OKADA YUMIKO (JP)
MIYAMOTO SACHIKO (JP)
SHIOBARA MAKI (JP)

International Classes:

A61K31/55; A61P37/08; C07C59/76; C07C59/84; C07C59/90; C07C69/738; C07C205/56; C07C229/22; C07D249/04; C07D487/04; C07F9/6561; (IPC1-7): C07D487/04; C07F9/09; A61K31/55; C07D249/04; C07C69/738; C07C59/90; C07C229/22; C07C205/56

Domestic Patent References:

WO1997000258A1	1997-01-03
WO1995018130A1	1995-07-06

Other References:

OBRECHT D., ET AL.: "5. A NOVEL AND EFFICIENT APPROACH FOR THE COMBINATORIAL SYNTHESIS OF STRUCTURALLY DIVERSE PYRIMIDINES ON SOLID SUPPORT.", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., CH, vol. 80., 1 January 1997 (1997-01-01), CH, pages 65 - 72., XP002915327, ISSN: 0018-019X, DOI: 10.1002/hlca.19970800106
See also references of EP 1026167A4

Attorney, Agent or Firm:

Sato, Kazuo (Fuji Building 2-3, Marunouchi 3-chome Chiyoda-ku Tokyo, JP)

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