Title:
TRIFLUOROACETHYDRAZIDE COMPOUND AS WELL AS PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN PREPARING MEDICAMENT
Document Type and Number:
WIPO Patent Application WO/2016/106760
Kind Code:
A1
Abstract:
Disclosed are a trifluoroacethydrazide compound as well as preparation and application thereof. The compound has a structure represented by general formula (I). The compound has multiple mechanisms of action, comprising inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, and the effect of scavenging free radicals and promoting neural differentiation, and thus has a desirable protective effect on neurocytes and can alleviate memory impairment of a scopolamine-induced mouse model. The compound can be used for preparing a medicament having a cell protective effect, which is used for preventing or treating diseases related to glutamate excitotoxicity, MEF2 imbalance or overproduction of free radicals, e.g., diseases related to neurodegeneration comprising senile dementia, Parkinson's disease, cerebral stroke and the like, and diseases related to free radicals such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.
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Inventors:
WANG YUQIANG (CN)
CHEN HAIYUN (CN)
ZHANG ZAIJUN (CN)
ZHANG GAOXIAO (CN)
YU PEI (CN)
SUN YEWEI (CN)
SHAN LUCHEN (CN)
TAO LIANG (CN)
CHEN HAIYUN (CN)
ZHANG ZAIJUN (CN)
ZHANG GAOXIAO (CN)
YU PEI (CN)
SUN YEWEI (CN)
SHAN LUCHEN (CN)
TAO LIANG (CN)
Application Number:
PCT/CN2015/000581
Publication Date:
July 07, 2016
Filing Date:
August 11, 2015
Export Citation:
Assignee:
GUAGNZHOU MAGPIE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D241/12; A61K31/4965; A61P25/00; C07C241/00
Foreign References:
| US20100305181A1 | 2010-12-02 | |||
| US20060276433A1 | 2006-12-07 |
Other References:
CHIRUTA, C. ET AL.: "Metabolism of a potent neuroprotective hydrazide", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 10, 24 March 2013 (2013-03-24), pages 2733 - 2741, XP028583444, ISSN: 0968-0896
WANG, M. ET AL.: "The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 2, 22 November 2012 (2012-11-22), pages 524 - 527, XP055202822, ISSN: 0960-894X
See also references of EP 3241824A4
WANG, M. ET AL.: "The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 2, 22 November 2012 (2012-11-22), pages 524 - 527, XP055202822, ISSN: 0960-894X
See also references of EP 3241824A4
Attorney, Agent or Firm:
PANTERRAIN IP ATTORNEYS (CN)
北京攀腾专利代理事务所 (CN)
北京攀腾专利代理事务所 (CN)
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