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Patent Searching and Data


Title:
TRIM72 AS POTENTIAL THERAPEUTIC TARGET FOR ALS THROUGH UBIQUITINATING MUTANT FUS PROTEIN
Document Type and Number:
WIPO Patent Application WO/2018/170796
Kind Code:
A1
Abstract:
Provided is a pharmaceutical composition comprising a scavenger, wherein the scavenger is used for clearing away mutant FUS. A method for treating or preventing or alleviating ALS is also provided.

Inventors:
JIA, Yichang (Qinghuayuan, Haidian District, Beijing 4, 100084, CN)
ZHANG, Xue (Qinghuayuan, Haidian District, Beijing 4, 100084, CN)
Application Number:
CN2017/077712
Publication Date:
September 27, 2018
Filing Date:
March 22, 2017
Export Citation:
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Assignee:
TSINGHUA UNIVERSITY (Qinghuayuan, Haidian District, Beijing 4, 100084, CN)
International Classes:
A61K38/53; A61K38/43; A61P21/00
Domestic Patent References:
WO2013036610A22013-03-14
WO2016109638A12016-07-07
WO2011142744A12011-11-17
WO2012135868A22012-10-04
WO2008054561A22008-05-08
WO2010011283A22010-01-28
Foreign References:
CN101797375A2010-08-11
CN105079810A2015-11-25
Other References:
VANCE, C. ET AL.: "ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules", HUMAN MOLECULAR GENETICS, vol. 22, no. 13, 7 March 2013 (2013-03-07), pages 2676 - 2688, XP055538530
ITO, D. ET AL.: "Nuclear Transport Impairment of Amyotrophic Lateral Sclerosis-Linked Mutations in FUS/TLS", ANNALS OF NEUROLOGY, vol. 69, no. 1, 1 January 2011 (2011-01-01), pages 152 - 162, XP055538558
WEISLEDER, N. ET AL.: "Recombinant MG 53 Protein can Increase Membrane Repair Capacity and Improve Pathology in Dystrophic Mouse Muscle", BIOPHYSICAL JOURNAL, vol. 102, no. 3, 31 January 2012 (2012-01-31), XP028893927
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (Room 301 Trade Building, Zhaolanyuan Tsinghua University, Qinghuayuan, Haidian District, Beijing 4, 100084, CN)
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